4-Methoxyindoline-2,3-dione

Base Information

• Chemical Name: 4-Methoxyindoline-2,3-dione
• CAS No.: 108937-87-7
• Molecular Formula: C9H7NO3
• Molecular Weight: 177.15700
• Hs Code.: 2933990090
• European Community (EC) Number: 830-052-7
• DSSTox Substance ID: DTXSID80464025
• Nikkaji Number: J2.071.622C
• Wikidata: Q82289197
• Mol file: 108937-87-7.mol

Synonyms:4-METHOXYINDOLINE-2,3-DIONE;108937-87-7;4-methoxy-1H-indole-2,3-dione;1H-Indole-2,3-dione, 4-methoxy-;4-methoxyisatin;4-methoxy-2,3-dihydro-1H-indole-2,3-dione;SCHEMBL281586;4-Methoxy-indoline-2,3-dione;DTXSID80464025;LTERBHLYBWXCPT-UHFFFAOYSA-N;AMY27458;MFCD10000746;AKOS006302637;SB64319;AS-35463;CS-0172645;2,3-Dihydro-4-methoxy-1H-indole-2,3-dione;EN300-93538;A910021;W-204683;Z1198272466

Chemical Property of 4-Methoxyindoline-2,3-dione

Chemical Property:

• PSA: 55.40000
• LogP: 0.96800
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 177.042593085
• Heavy Atom Count: 13
• Complexity: 251

Purity/Quality:

98% ^*data from raw suppliers

4-Methoxyindoline-2,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1C(=O)C(=O)N2

Technology Process of 4-Methoxyindoline-2,3-dione

There total 10 articles about 4-Methoxyindoline-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

[2-(2,2-Dimethyl-propionylamino)-6-methoxy-phenyl]-oxo-acetic acid ethyl ester → 4-methoxyisatin (108937-87-7)

Guidance literature:

With hydrogenchloride; In 1,2-dimethoxyethane; Heating;

DOI:10.1016/0040-4039(94)85299-5

Reference yield: 57.0%

C9H8BrCl3N2O2 → 4-methoxyisatin (108937-87-7)

Guidance literature:

With sulfuric acid; at 40 - 60 ℃; for 0.5h;

Reference yield: 56.0%

4-methoxy-1H-indole (4837-90-5) → 4-methoxyisatin (108937-87-7)

Guidance literature:

With pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; oxygen; silver nitrate; benzoic acid; at 65 ℃; for 48h;

DOI:10.1039/c5ra04106f

upstream raw materials:

7-methoxy-3-methyl-3-thiomethyl oxindole

oxalyl dichloride

m-anisidine hydrochloride

N-(3-methoxyphenyl)pivalamide

Downstream raw materials:

(2-Ethyl-phenoxy)-acetic acid [4-methoxy-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-hydrazide

4-Methoxy-1H-indazole-3-carboxylic acid