4-Methoxyindazole-3-carboxylic acid

Base Information

• Chemical Name: 4-Methoxyindazole-3-carboxylic acid
• CAS No.: 865887-02-1
• Molecular Formula: C₉H₈N₂O₃
• Molecular Weight: 192.174
• Hs Code.: 2933990090
• Mol file: 865887-02-1.mol

Synonyms:4-Methoxy-1H-indazole-3-carboxylic acid;4-Methoxyindazole-3-carboxylic acid;

Chemical Property of 4-Methoxyindazole-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.52E-09mmHg at 25°C
• Refractive Index: 1.688
• Boiling Point: 467.6 °C at 760 mmHg
• PKA: 14.85±0.40(Predicted)
• Flash Point: 236.6 °C
• PSA: 75.21000
• Density: 1.459 g/cm³
• LogP: 1.26970
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-Methoxy-1H-indazole-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methoxy-1H-indazole-3-carboxylic Acid is used in the preparation of tricyclic compounds such as alpha-7 nicotinic acetylcholine receptor ligands for treatment of central nervous system disorders.

Technology Process of 4-Methoxyindazole-3-carboxylic acid

There total 2 articles about 4-Methoxyindazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxyisatin (108937-87-7) → 4-Methoxy-1H-indazole-3-carboxylic acid (865887-02-1)

Guidance literature:

4-methoxyindole-2,3-dione; With sodium hydroxide; In water; at 30 - 40 ℃; for 0.5h;

With sodium nitrite; In water; at 0 ℃; for 0.333333h;

With hydrogenchloride; sulfuric acid; tin(ll) chloride; more than 3 stages; Product distribution / selectivity;

Reference yield: 100.0%

C10H10N2O3 (865887-07-6) → 4-Methoxy-1H-indazole-3-carboxylic acid (865887-02-1)

Guidance literature:

With methanol; sodium hydroxide; water; at 60 ℃; for 3h; Product distribution / selectivity;

Reference yield: 5.0%

methanol (67-56-1) + 4-Methoxy-1H-indazole-3-carboxylic acid (865887-02-1) → C10H10N2O3 (865887-07-6)

Guidance literature:

With acetyl chloride; at 0 ℃; for 4h; Heating / reflux;

upstream raw materials:

4-methoxyisatin

C₁₀H₁₀N₂O₃

Downstream raw materials:

C₁₀H₁₀N₂O₃

Refernces