2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido-[3,4-d]pyrimidin-7-yl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Base Information

Chemical Name:2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido-[3,4-d]pyrimidin-7-yl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide
CAS No.:159780-61-7
Molecular Formula:C₂₈H₃₇F₃N₄O₅Si
Molecular Weight:594.706
Hs Code.:

2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido-[3,4-d]pyrimidin-7-yl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

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Chemical Property of 2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido-[3,4-d]pyrimidin-7-yl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

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Technology Process of 2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido-[3,4-d]pyrimidin-7-yl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

There total 13 articles about 2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido-[3,4-d]pyrimidin-7-yl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026063-53-5
(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-4-methylcarbamoyl-2-oxo-6-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester

: 159780-61-7
2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido-[3,4-d]pyrimidin-7-yl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 2.5h;
DOI:10.1021/jm950684z

Reference yield:

: 2397-26-4
N,N-dimethyl(chlorophenylmethylene)ammonium chloride

: 159780-61-7
2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido-[3,4-d]pyrimidin-7-yl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) THF, hexane, RT, 4.5 h, 2.) THF, hexane, RT, 1 h

2: 48 percent / 24 h / 120 °C / 1 Torr

3: 96 percent / LiI / pyridine / 14 h / Heating

4: 84 percent / diphenyl phosphoroazidate, TEA / dioxane / 4 h / Heating

5: 53 percent / aq. LiOH*H₂O / ethanol / 7 h / 0 °C

6: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature

7: dimethylformamide / 2.5 h / 120 °C

With lithium hydroxide; TEA; diphenyl phosphoryl azide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide; In 1,4-dioxane; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950684z

Reference yield:

: 174740-67-1
dimethyl <2-(ethoxycarbonyl)ethylidene>malonate

: 159780-61-7
2-(3-Methyl-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydropyrido-[3,4-d]pyrimidin-7-yl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) THF, hexane, RT, 4.5 h, 2.) THF, hexane, RT, 1 h

2: 48 percent / 24 h / 120 °C / 1 Torr

3: 96 percent / LiI / pyridine / 14 h / Heating

4: 84 percent / diphenyl phosphoroazidate, TEA / dioxane / 4 h / Heating

5: 53 percent / aq. LiOH*H₂O / ethanol / 7 h / 0 °C

6: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature

7: dimethylformamide / 2.5 h / 120 °C

With lithium hydroxide; TEA; diphenyl phosphoryl azide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide; In 1,4-dioxane; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950684z