N--L-alanyl>-(4RS)-4--N-methylamino>-L-proline ethyl ester S,S-dioxide

Base Information

Chemical Name:N--L-alanyl>-(4RS)-4--N-methylamino>-L-proline ethyl ester S,S-dioxide
CAS No.:103580-39-8
Molecular Formula:C₃₁H₄₃ClN₆O₉S₂
Molecular Weight:743.302
Hs Code.:

N-<N'-<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-alanyl>-(4RS)-4-<N-<(6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazin-3-yl)methyl>-N-methylamino>-L-proline ethyl ester S,S-dioxide

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Chemical Property of N--L-alanyl>-(4RS)-4--N-methylamino>-L-proline ethyl ester S,S-dioxide

Chemical Property:

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Technology Process of N--L-alanyl>-(4RS)-4--N-methylamino>-L-proline ethyl ester S,S-dioxide

There total 5 articles about N--L-alanyl>-(4RS)-4--N-methylamino>-L-proline ethyl ester S,S-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92893-50-0
N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine

: 103580-39-8,103665-10-7
N--L-alanyl>-(4RS)-4--N-methylamino>-L-proline ethyl ester S,S-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 3.5 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / Ambient temperature

3: 95 percent / pyridinium chlorochromate / CH₂Cl₂ / 72 h / Ambient temperature

4: Zn, HOAc / ethanol / Ambient temperature

5: 1.) DMF, MgSO₄, 2.) NaBCNH₃ / 1.) RT, 30 min, 2.) overnight

With oxalyl dichloride; sodium cyanoborohydride; magnesium sulfate; acetic acid; triethylamine; N,N-dimethyl-formamide; pyridinium chlorochromate; zinc; In ethanol; dichloromethane;
DOI:10.1021/jm00168a013

Reference yield:

: 92893-51-1
(S)-2-[((S)-1-Chlorocarbonyl-ethyl)-(2,2,2-trichloro-ethoxycarbonyl)-amino]-4-phenyl-butyric acid ethyl ester

: 103580-39-8,103665-10-7
N--L-alanyl>-(4RS)-4--N-methylamino>-L-proline ethyl ester S,S-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / Ambient temperature

2: 95 percent / pyridinium chlorochromate / CH₂Cl₂ / 72 h / Ambient temperature

3: Zn, HOAc / ethanol / Ambient temperature

4: 1.) DMF, MgSO₄, 2.) NaBCNH₃ / 1.) RT, 30 min, 2.) overnight

With sodium cyanoborohydride; magnesium sulfate; acetic acid; triethylamine; N,N-dimethyl-formamide; pyridinium chlorochromate; zinc; In ethanol; dichloromethane;
DOI:10.1021/jm00168a013

Reference yield:

: 103580-24-1
N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-prolin-4-one ethyl ester

: 103580-39-8,103665-10-7
N--L-alanyl>-(4RS)-4--N-methylamino>-L-proline ethyl ester S,S-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: Zn, HOAc / ethanol / Ambient temperature

2: 1.) DMF, MgSO₄, 2.) NaBCNH₃ / 1.) RT, 30 min, 2.) overnight

With sodium cyanoborohydride; magnesium sulfate; acetic acid; N,N-dimethyl-formamide; zinc; In ethanol;
DOI:10.1021/jm00168a013