103580-24-1

Upstream product

• 92893-51-1 (S)-2-[((S)-1-Chlorocarbonyl-ethyl)-(2,2,2-trichloro-ethoxycarbonyl)-amino]-4-phenyl-butyric acid ethyl ester 
• 92893-50-0 N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine 
• 103654-87-1 N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-4-hydroxyproline ethyl ester 

Downstream Products

• 103665-12-9 N-[N'-((1S)-1-carboxy-3-phenylpropyl)-L-alanyl]-4-[N²-(3-sulfamyl-4-chlorobenzoyl)hydrazino]-L-proline 
• 103580-40-1 N--L-alanyl>-(4RS)-4--N-methylamino>-L-proline S,S-dioxide 
• 126373-75-9 1'-[N'-((1S)-1-carboxy-3-phenylpropyl)-L-alanyl]-5'-carboxy-7-(aminosulfonyl)-6-chlorospiro(2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine) S,S-dioxide 
• 103580-37-6 N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-4-2-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester 
• 103580-39-8 N--L-alanyl>-(4RS)-4--N-methylamino>-L-proline ethyl ester S,S-dioxide 
• 126373-61-3 1'--L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide 
• 126257-69-0 N--L-alanyl>-4-2-(3-sulfamyl-4-chlorobenzoyl)hydrazino>-L-proline ethyl ester 
• 103632-12-8 1'--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide 

Relevant academic research and scientific papers

Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives

Compounds 1a-g consisting of enalaprilat covalently bonded to aryl sulfonamides, including several known thiazide diuretics, were synthesized and tested for ACE inhibitory and diuretic and overall antihypertensive effects. All compounds were potent ACE in

ANTIHYPERTENSIVE SPIRO-CYCLIC COMPOUNDS

Compounds having the general structure STR1 and their pharmaceutically acceptable salts, wherein the substituents are defined herein, which exhibit antihypertensive activity.