6-acetonyldihydrochelerythrine

Base Information

Chemical Name:6-acetonyldihydrochelerythrine
CAS No.:15575-49-2
Molecular Formula:C₂₄H₂₃NO₅
Molecular Weight:405.45
Hs Code.:

Synonyms:

Suppliers and Price of 6-acetonyldihydrochelerythrine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-acetonyldihydrochelerythrine

Chemical Property:

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Technology Process of 6-acetonyldihydrochelerythrine

There total 16 articles about 6-acetonyldihydrochelerythrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.6%

: 34316-15-9
chelerythrinium

: 67-64-1
acetone

: 15575-49-2,22864-92-2,128778-79-0
6-acetonyldihydrochelerythrine

Guidance literature:: With sodium carbonate; In water; for 7h; Reflux;
DOI:10.1080/14786419.2010.482055

Reference yield:

: 180411-11-4
6-bromonaphtho[2,3-d][1,3]dioxol-5-ol

: 15575-49-2,22864-92-2,128778-79-0
6-acetonyldihydrochelerythrine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 0.25 h / 20 °C / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydride / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

3.1: sodium hydroxide / water; methanol / 48 h / Inert atmosphere; Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

5.2: 5 h / 0 - 20 °C / Inert atmosphere

6.1: bis(pinacol)diborane; potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / dimethyl sulfoxide / 16 h / Inert atmosphere

7.1: sodium acetate; iodine / ethanol / 2 h / Inert atmosphere; Reflux

8.1: sodium carbonate / water / 6 h / Inert atmosphere; Reflux

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; iodine; potassium acetate; sodium acetate; sodium hydride; sodium carbonate; bis(pinacol)diborane; sodium hydroxide; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: |Smiles Aromatic Rearrangement;
DOI:10.1016/j.bmc.2016.04.059

Reference yield:

: 6-bromo-N-(6-bromo-2,3-dimethoxybenzyl)naphtho[2,3-d][1,3]dioxol-5-amine

: 15575-49-2,22864-92-2,128778-79-0
6-acetonyldihydrochelerythrine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 5 h / 0 - 20 °C / Inert atmosphere

2.1: bis(pinacol)diborane; potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / dimethyl sulfoxide / 16 h / Inert atmosphere

3.1: sodium acetate; iodine / ethanol / 2 h / Inert atmosphere; Reflux

4.1: sodium carbonate / water / 6 h / Inert atmosphere; Reflux

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; iodine; potassium acetate; sodium acetate; sodium hydride; sodium carbonate; bis(pinacol)diborane; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.04.059