Piv-L-trans(βPh)Pro-D-Phe-NHMe

Base Information

• Chemical Name: Piv-L-trans(βPh)Pro-D-Phe-NHMe
• CAS No.: 1353499-10-1
• Molecular Formula: C₂₆H₃₃N₃O₃
• Molecular Weight: 435.566
• Mol file: 1353499-10-1.mol

Synonyms:

Chemical Property of Piv-L-trans(βPh)Pro-D-Phe-NHMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Piv-L-trans(βPh)Pro-D-Phe-NHMe

There total 3 articles about Piv-L-trans(βPh)Pro-D-Phe-NHMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H25N3O2 + pivaloyl chloride (3282-30-2) → Piv-L-trans(βPh)Pro-D-Phe-NHMe (1353499-10-1)

Guidance literature:

With 4-methyl-morpholine; In chloroform; at 20 ℃; for 24h;

DOI:10.1039/c1ob06561k

Reference yield:

(2S,3R)-1-(tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid (123724-21-0,210420-48-7,149252-59-5) → Piv-L-trans(βPh)Pro-D-Phe-NHMe (1353499-10-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / acetonitrile / 0.17 h

1.2: 96 h

2.1: hydrogenchloride; water / ethyl acetate / 2 h / 20 °C

3.1: 4-methyl-morpholine / chloroform / 24 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; water; In chloroform; ethyl acetate; acetonitrile;

DOI:10.1039/c1ob06561k

Reference yield:

(R)-1-(methylaminocarbonyl)-3-phenylpropanaminium chloride (111321-55-2) → Piv-L-trans(βPh)Pro-D-Phe-NHMe (1353499-10-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / acetonitrile / 0.17 h

1.2: 96 h

2.1: hydrogenchloride; water / ethyl acetate / 2 h / 20 °C

3.1: 4-methyl-morpholine / chloroform / 24 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; water; In chloroform; ethyl acetate; acetonitrile;

DOI:10.1039/c1ob06561k

upstream raw materials:

pivaloyl chloride

(2S,3R)-1-(tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid

(R)-1-(methylaminocarbonyl)-3-phenylpropanaminium chloride