3-Bromo-2-hydroxy-4,5-dimethoxybenzaldehyde

Base Information

• Chemical Name: 3-Bromo-2-hydroxy-4,5-dimethoxybenzaldehyde
• CAS No.: 109765-52-8
• Molecular Formula: C9H9BrO4
• Molecular Weight: 261.072
• DSSTox Substance ID: DTXSID10552166
• Nikkaji Number: J2.742.409K
• Wikidata: Q82432223
• Mol file: 109765-52-8.mol

Synonyms:109765-52-8;3-Bromo-2-hydroxy-4,5-dimethoxybenzaldehyde;SCHEMBL11999813;DTXSID10552166

Chemical Property of 3-Bromo-2-hydroxy-4,5-dimethoxybenzaldehyde

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 259.96842
• Heavy Atom Count: 14
• Complexity: 199

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=C(C(=C1)C=O)O)Br)OC

Technology Process of 3-Bromo-2-hydroxy-4,5-dimethoxybenzaldehyde

There total 2 articles about 3-Bromo-2-hydroxy-4,5-dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-hydroxy-4,5-dimethoxybenzaldehyde (14382-91-3) → 3-bromo-2-hydroxy-4,5-dimethoxybenzaldehyde (109765-52-8)

Guidance literature:

2-hydroxy-4,5-dimethoxybenzaldehyde; In acetonitrile; at 80 ℃; for 0.166667h;

With N-Bromosuccinimide; In acetonitrile; at 80 ℃; for 8h; regioselective reaction;

DOI:10.1021/jo300731z

Reference yield:

asaraldehyde (4460-86-0,14374-62-0) → 3-bromo-2-hydroxy-4,5-dimethoxybenzaldehyde (109765-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / BBr₃ / CH₂Cl₂ / 16 h / 20 °C

2: 54 percent / bromine; NaOAc; acetic acid / 2 h / 20 °C

With bromine; sodium acetate; boron tribromide; acetic acid; In dichloromethane;

DOI:10.1021/ol052744t

Reference yield: 96.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 3-bromo-2-hydroxy-4,5-dimethoxybenzaldehyde (109765-52-8) → 3-bromo-2-(tert-butyl-dimethyl-silanyloxy)-4,5-dimethoxy-benzaldehyde (905291-15-8)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1021/jm100531u

upstream raw materials:

2-hydroxy-4,5-dimethoxybenzaldehyde

asaraldehyde

Downstream raw materials:

3-bromo-1,2-dihydroxy-4,5-dimethoxybenzene

3-bromo-2-(tert-butyl-dimethyl-silanyloxy)-4,5-dimethoxy-benzaldehyde

[3-bromo-2-(tert-butyl-dimethyl-silanyloxy)-4,5-dimethoxy-phenyl]-methanol

3-bromo-4,5-dimethoxy-3,5-cyclohexadiene-1,2-dione

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 109765-52-8 Benzaldehyde, 3-bromo-2-hydroxy-4,5-dimethoxy-

Send

Send

Metric Ton KG G Pound L ML

Send

Send