3-(2,5-dimethoxyphenyl)-3-hydroxy-4-methoxy-1(3H)-isobenzofuranone

Base Information

• Chemical Name: 3-(2,5-dimethoxyphenyl)-3-hydroxy-4-methoxy-1(3H)-isobenzofuranone
• CAS No.: 121364-88-3
• Molecular Formula: C₁₇H₁₆O₆
• Molecular Weight: 316.31
• Mol file: 121364-88-3.mol

Synonyms:

Chemical Property of 3-(2,5-dimethoxyphenyl)-3-hydroxy-4-methoxy-1(3H)-isobenzofuranone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2,5-dimethoxyphenyl)-3-hydroxy-4-methoxy-1(3H)-isobenzofuranone

There total 8 articles about 3-(2,5-dimethoxyphenyl)-3-hydroxy-4-methoxy-1(3H)-isobenzofuranone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxyphthalic acid (14963-97-4) → 3-(2,5-dimethoxyphenyl)-3-hydroxy-4-methoxy-1(3H)-isobenzofuranone (121364-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / Amberlyst 15 beads / 48 h / Heating

2: thionyl chloride / 2 h / 20 °C

3: 30 percent / AlCl₃ / nitrobenzene / 18 h / 20 °C

With aluminium trichloride; thionyl chloride; Amberlyst 15 beads; In nitrobenzene;

Reference yield:

dimethyl 3-methoxyphthalate (32136-52-0) → 3-(2,5-dimethoxyphenyl)-3-hydroxy-4-methoxy-1(3H)-isobenzofuranone (121364-88-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / 7percent KOH / H₂O; ethanol / other reagents and solvents at various temperatures

2: 65 percent / Amberlyst 15 beads / 48 h / Heating

3: thionyl chloride / 2 h / 20 °C

4: 30 percent / AlCl₃ / nitrobenzene / 18 h / 20 °C

With potassium hydroxide; aluminium trichloride; thionyl chloride; Amberlyst 15 beads; In ethanol; water; nitrobenzene;

Reference yield:

2-methoxy-6-methoxycarbonylbenzoic acid (60314-07-0) → 3-(2,5-dimethoxyphenyl)-3-hydroxy-4-methoxy-1(3H)-isobenzofuranone (121364-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / 20 °C

2: 30 percent / AlCl₃ / nitrobenzene / 18 h / 20 °C

With aluminium trichloride; thionyl chloride; In nitrobenzene;

upstream raw materials:

3-methoxyphthalic anhydride

1,4-dimethoxybezene

2-methyl 3-methoxyphthalate

2-methoxy-6-methoxycarbonylbenzoic acid

Downstream raw materials:

2-<2,5-dimethoxybenzyl>-3-methoxybenzoic acid

Refernces

• 1、 Hansen Jr.,Pappo,Garland. "A stereospecific total synthesis of the anthracyclinones (±)-daunomycinone and (±)-isodaunomycinone". . p. 4244 - 4253. Retrieved 2007/10/02.