(-)-N-benzyloxycarbonyl-2-nitro-3,4-dihydroxyphenylalanine methyl ester

Base Information

• Chemical Name: (-)-N-benzyloxycarbonyl-2-nitro-3,4-dihydroxyphenylalanine methyl ester
• CAS No.: 161156-54-3
• Molecular Formula: C₂₀H₂₂N₂O₈
• Molecular Weight: 418.403
• Mol file: 161156-54-3.mol

Synonyms:

Chemical Property of (-)-N-benzyloxycarbonyl-2-nitro-3,4-dihydroxyphenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-N-benzyloxycarbonyl-2-nitro-3,4-dihydroxyphenylalanine methyl ester

There total 2 articles about (-)-N-benzyloxycarbonyl-2-nitro-3,4-dihydroxyphenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(S)-methyl 2-(benzyloxycarbonylamino)-3-(3,4-dimethoxyphenyl)propanoate (128595-72-2) → (-)-N-benzyloxycarbonyl-2-nitro-3,4-dihydroxyphenylalanine methyl ester (161156-54-3)

Guidance literature:

With nitric acid; acetic acid; for 3h; Ambient temperature;

DOI:10.1016/0223-5234(94)90110-4

Reference yield:

N-benzyloxycarbonyl-3,4-dimethoxy-L-phenylalanine (73404-23-6) → (-)-N-benzyloxycarbonyl-2-nitro-3,4-dihydroxyphenylalanine methyl ester (161156-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / K₂CO₃ / acetone / 6 h / Heating

2: 76 percent / 65percent HNO₃, acetic acid / 3 h / Ambient temperature

With nitric acid; potassium carbonate; acetic acid; In acetone;

DOI:10.1016/0223-5234(94)90110-4

upstream raw materials:

(S)-methyl 2-(benzyloxycarbonylamino)-3-(3,4-dimethoxyphenyl)propanoate

N-benzyloxycarbonyl-3,4-dimethoxy-L-phenylalanine