1-[5-[2-(4-fluorophenyl)ethynyl]-2-pyridyl]-2-imidazol-1-yl-N-methoxyethanimine

Base Information

Chemical Name:1-[5-[2-(4-fluorophenyl)ethynyl]-2-pyridyl]-2-imidazol-1-yl-N-methoxyethanimine
CAS No.:1463856-19-0
Molecular Formula:C₁₉H₁₅FN₄O
Molecular Weight:334.353
Hs Code.:

Synonyms:

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Chemical Property of 1-[5-[2-(4-fluorophenyl)ethynyl]-2-pyridyl]-2-imidazol-1-yl-N-methoxyethanimine

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Technology Process of 1-[5-[2-(4-fluorophenyl)ethynyl]-2-pyridyl]-2-imidazol-1-yl-N-methoxyethanimine

There total 5 articles about 1-[5-[2-(4-fluorophenyl)ethynyl]-2-pyridyl]-2-imidazol-1-yl-N-methoxyethanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 223463-13-6
2-iodo-5-bromopyridine

: 1463856-19-0
1-[5-[2-(4-fluorophenyl)ethynyl]-2-pyridyl]-2-imidazol-1-yl-N-methoxyethanimine

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

1.2: 0.5 h / 20 °C / Cooling with ice

2.1: manganese(IV) oxide / dichloromethane / 40 °C

3.1: hydrogen bromide; bromine; acetic acid / methanol / 1 h / 0 - 70 °C

4.1: tetrahydrofuran / 2 h / 0 °C / Cooling with ice

5.1: sodium acetate / ethanol / 90 °C

6.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

With manganese(IV) oxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; bromine; isopropylmagnesium bromide; sodium acetate; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 159533-68-3,870694-36-3
2-(1-hydroxyethyl)-5-bromopyridine

: 1463856-19-0
1-[5-[2-(4-fluorophenyl)ethynyl]-2-pyridyl]-2-imidazol-1-yl-N-methoxyethanimine

Guidance literature:: Multi-step reaction with 5 steps

1: manganese(IV) oxide / dichloromethane / 40 °C

2: hydrogen bromide; bromine; acetic acid / methanol / 1 h / 0 - 70 °C

3: tetrahydrofuran / 2 h / 0 °C / Cooling with ice

4: sodium acetate / ethanol / 90 °C

5: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

With manganese(IV) oxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; bromine; sodium acetate; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 214701-49-2
1-(5-bromopyridin-2-yl)ethanone

: 1463856-19-0
1-[5-[2-(4-fluorophenyl)ethynyl]-2-pyridyl]-2-imidazol-1-yl-N-methoxyethanimine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide; bromine; acetic acid / methanol / 1 h / 0 - 70 °C

2: tetrahydrofuran / 2 h / 0 °C / Cooling with ice

3: sodium acetate / ethanol / 90 °C

4: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; bromine; sodium acetate; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;