1-(5-BROMOPYRIDIN-2-YL)-ETHANOL

Base Information

• Chemical Name: 1-(5-BROMOPYRIDIN-2-YL)-ETHANOL
• CAS No.: 159533-68-3
• Molecular Formula: C₇H₈BrNO
• Molecular Weight: 202.051
• Hs Code.: 2933399090
• Mol file: 159533-68-3.mol

Synonyms:1-(5-Bromopyridin-2-yl)ethanol

Chemical Property of 1-(5-BROMOPYRIDIN-2-YL)-ETHANOL

Chemical Property:

• Vapor Pressure: 0.00263mmHg at 25°C
• Refractive Index: 1.578
• Boiling Point: 274.4°Cat760mmHg
• Flash Point: 119.8°C
• PSA: 33.12000
• Density: 1.555g/cm³
• LogP: 1.89740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(5-bromopyridin-2-yl)ethanol 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-BROMOPYRIDIN-2-YL)-ETHANOL

There total 10 articles about 1-(5-BROMOPYRIDIN-2-YL)-ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-bromo-pyridine-2-carbaldehyde (31181-90-5) + methylmagnesium bromide (75-16-1) → 2-(1-hydroxyethyl)-5-bromopyridine (159533-68-3,870694-36-3)

Guidance literature:

In tetrahydrofuran; toluene; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1039/d1cc03804d

Reference yield: 91.9%

1-(5-bromopyridin-2-yl)ethanone (214701-49-2) → 2-(1-hydroxyethyl)-5-bromopyridine (159533-68-3,870694-36-3)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃; for 0.166667h;

Reference yield: 91.0%

1-(5-bromopyridin-2-yl)ethanone (214701-49-2) → 1-(5-bromopyridin-2-yl)ethan-1-ol (159533-68-3,870694-36-3)

Guidance literature:

1-(5-bromopyridin-2-yl)ethanone; With trimethylaluminum; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; 3,3'-bis-(3,5-bis-trifluoromethyl-phenyl)-[1,1']binaphthalenyl-2,2'-diol; In toluene; at 20 ℃; for 2h; Glovebox; Inert atmosphere;

With methanol; for 0.5h; enantioselective reaction;

DOI:10.1021/jacs.9b10364

upstream raw materials:

2-(1-hydroxyethyl)-5-bromopyridine

5-bromo-pyridine-2-carbaldehyde

methylmagnesium bromide

1-(5-bromopyridin-2-yl)ethanone

Downstream raw materials:

(1R)-1-(5-bromopyridin-2-yl)ethanol

(1S)-1-(5-bromopyridin-2-yl)ethanol

2-bromo-1-(5-bromopyridin-2-yl)ethanone hydrobromide

(R)-1-(5-bromopyridin-2-yl)ethanamine