[2-methyl-4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]acetic acid methyl ester

Base Information

Chemical Name:[2-methyl-4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]acetic acid methyl ester
CAS No.:1428761-12-9
Molecular Formula:C₁₃H₁₄N₂O₃
Molecular Weight:246.266
Hs Code.:

Synonyms:

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Chemical Property of [2-methyl-4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]acetic acid methyl ester

Chemical Property:

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Technology Process of [2-methyl-4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]acetic acid methyl ester

There total 8 articles about [2-methyl-4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428761-11-8
[4-(N-hydroxycarbamimidoyl)-2-methylphenyl]acetic acid methyl ester

: 108-24-7
acetic anhydride

: 1428761-12-9
[2-methyl-4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]acetic acid methyl ester

Guidance literature:: for 12h; Reflux;

Reference yield:

: 99548-55-7
4-bromo-2-methyl-benzoic acid methyl ester

: 1428761-12-9
[2-methyl-4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: lithium aluminium tetrahydride / dichloromethane / 16 h / 0 - 20 °C

2: phosphorus tribromide / dichloromethane / 3 h / 0 - 20 °C

3: tetrabutylammomium bromide / dichloromethane; water / 16 h / 0 - 20 °C

4: thionyl chloride / 16 h / 0 - 20 °C

5: triphenylphosphine / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

6: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 2 h / Reflux

7: 12 h / Reflux

With lithium aluminium tetrahydride; thionyl chloride; hydroxylamine hydrochloride; tetrabutylammomium bromide; phosphorus tribromide; sodium hydrogencarbonate; triphenylphosphine; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 1428761-12-9
[2-methyl-4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: phosphorus tribromide / dichloromethane / 3 h / 0 - 20 °C

2: tetrabutylammomium bromide / dichloromethane; water / 16 h / 0 - 20 °C

3: thionyl chloride / 16 h / 0 - 20 °C

4: triphenylphosphine / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

5: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 2 h / Reflux

6: 12 h / Reflux

With thionyl chloride; hydroxylamine hydrochloride; tetrabutylammomium bromide; phosphorus tribromide; sodium hydrogencarbonate; triphenylphosphine; In 1,4-dioxane; ethanol; dichloromethane; water;