N-tert-butyloxycarbonyl-glutamyl-glycylglycine benzyl ester

Base Information Edit

Chemical Name:N-tert-butyloxycarbonyl-glutamyl-glycylglycine benzyl ester
CAS No.:84983-78-8
Molecular Formula:C₂₁H₃₀N₄O₇
Molecular Weight:450.492
Hs Code.:
Mol file:84983-78-8.mol

Synonyms:

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Chemical Property of N-tert-butyloxycarbonyl-glutamyl-glycylglycine benzyl ester Edit

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Technology Process of N-tert-butyloxycarbonyl-glutamyl-glycylglycine benzyl ester

There total 3 articles about N-tert-butyloxycarbonyl-glutamyl-glycylglycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 15387-45-8
Boc-Gln-ONp

: 1738-82-5
glycylglycine benzyl ester p-toluene sulfonate salt

: 84983-78-8
N-tert-butyloxycarbonyl-glutamyl-glycylglycine benzyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

Reference yield:

: 1738-68-7
Gly-OBz

: 84983-78-8
N-tert-butyloxycarbonyl-glutamyl-glycylglycine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / NMM, HOBt, WSCl / tetrahydrofuran / 16 h / 4 °C

2: 1.) TFA, anisole 2.) NMM / 1.) room temperature, 20 min 2.) DMF, room temperature, 18 h.

With 4-methyl-morpholine; benzotriazol-1-ol; methoxybenzene; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1248/cpb.30.4448

Reference yield:

: 15387-45-8
Boc-Gln-ONp

: 31972-51-7
N-(tert-butoxycarbonyl)glycylglycine benzyl ester

: 84983-78-8
N-tert-butyloxycarbonyl-glutamyl-glycylglycine benzyl ester

Guidance literature:: With 4-methyl-morpholine; methoxybenzene; trifluoroacetic acid; Yield given. Multistep reaction; 1.) room temperature, 20 min 2.) DMF, room temperature, 18 h.;
DOI:10.1248/cpb.30.4448