Technology Process of 2-(4-fluoro-3-methylphenyl)-4-(t-butyldimethylsilyl)-oxy-6,6-dimethylcyclohex-1-enecarboxaldehyde
There total 7 articles about 2-(4-fluoro-3-methylphenyl)-4-(t-butyldimethylsilyl)-oxy-6,6-dimethylcyclohex-1-enecarboxaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) BF3*OEt, 2.) Triton B / 1.) 0-5 deg C, 5 d, 2.) MeOH, reflux, 1 h
2: NaBH4 / methanol / 1 h
3: imidazole / CH2Cl2
4: LAH / tetrahydrofuran / 18 h / 0 °C
5: 1.) triethylamine, sulfur trioxide-pyridine complex, 2.) potassium t-butoxide / 1.) DMSO, 1 h, 2.) THF, 2 h
With
1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; potassium tert-butylate; sulfur trioxide pyridine complex; N-benzyl-trimethylammonium hydroxide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0223-5234(92)90095-I
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 75 percent / NaH / diethyl ether / 2 h / Heating
2: 1.) BF3*OEt, 2.) Triton B / 1.) 0-5 deg C, 5 d, 2.) MeOH, reflux, 1 h
3: NaBH4 / methanol / 1 h
4: imidazole / CH2Cl2
5: LAH / tetrahydrofuran / 18 h / 0 °C
6: 1.) triethylamine, sulfur trioxide-pyridine complex, 2.) potassium t-butoxide / 1.) DMSO, 1 h, 2.) THF, 2 h
With
1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; potassium tert-butylate; sulfur trioxide pyridine complex; N-benzyl-trimethylammonium hydroxide; sodium hydride; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/0223-5234(92)90095-I
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) BF3*OEt, 2.) Triton B / 1.) 0-5 deg C, 5 d, 2.) MeOH, reflux, 1 h
2: NaBH4 / methanol / 1 h
3: imidazole / CH2Cl2
4: LAH / tetrahydrofuran / 18 h / 0 °C
5: 1.) triethylamine, sulfur trioxide-pyridine complex, 2.) potassium t-butoxide / 1.) DMSO, 1 h, 2.) THF, 2 h
With
1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; potassium tert-butylate; sulfur trioxide pyridine complex; N-benzyl-trimethylammonium hydroxide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0223-5234(92)90095-I
