Technology Process of 7-[(2,6-Dichlorophenyl)amino]-N-hexyl-2-methyl-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxamide
There total 9 articles about 7-[(2,6-Dichlorophenyl)amino]-N-hexyl-2-methyl-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: sulfuric acid; nitric acid / water / 14 h / 0 - 5 °C
2.1: sulfuric acid / ethanol / 24 h / Reflux
3.1: triethylamine / tetrahydrofuran / 0 - 26 °C
4.1: sodium methylate / methanol; water / 0 - 26 °C
5.1: aluminum (III) chloride / 1,2-dichloro-ethane / Reflux
6.1: hydrogenchloride; iron / methanol; water / 2 h / Reflux
7.1: acetonitrile / 24 h / 22 - 26 °C
7.2: 22 - 26 °C
8.1: sulfuric acid; potassium nitrate / water / 0.5 h / 10 - 15 °C
9.1: indium; acetic acid / benzene / Inert atmosphere; Reflux
10.1: methanol; sodium hydroxide / 3 h / Reflux
11.1: thionyl chloride / benzene / 3 h / 5 °C / Reflux
11.2: 22 - 26 °C / Inert atmosphere
With
hydrogenchloride; methanol; aluminum (III) chloride; indium; thionyl chloride; sulfuric acid; nitric acid; sodium methylate; iron; acetic acid; potassium nitrate; triethylamine; sodium hydroxide;
sulfuric acid;
In
tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; acetonitrile; benzene;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sulfuric acid / ethanol / 24 h / Reflux
2.1: triethylamine / tetrahydrofuran / 0 - 26 °C
3.1: sodium methylate / methanol; water / 0 - 26 °C
4.1: aluminum (III) chloride / 1,2-dichloro-ethane / Reflux
5.1: hydrogenchloride; iron / methanol; water / 2 h / Reflux
6.1: acetonitrile / 24 h / 22 - 26 °C
6.2: 22 - 26 °C
7.1: sulfuric acid; potassium nitrate / water / 0.5 h / 10 - 15 °C
8.1: indium; acetic acid / benzene / Inert atmosphere; Reflux
9.1: methanol; sodium hydroxide / 3 h / Reflux
10.1: thionyl chloride / benzene / 3 h / 5 °C / Reflux
10.2: 22 - 26 °C / Inert atmosphere
With
hydrogenchloride; methanol; aluminum (III) chloride; indium; thionyl chloride; sulfuric acid; sodium methylate; iron; acetic acid; potassium nitrate; triethylamine; sodium hydroxide;
sulfuric acid;
In
tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; acetonitrile; benzene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: methanol; sodium hydroxide / 3 h / Reflux
2.1: thionyl chloride / benzene / 3 h / 5 °C / Reflux
2.2: 22 - 26 °C / Inert atmosphere
With
methanol; thionyl chloride; sodium hydroxide;
In
benzene;
