1-[(2-Fluorobenzoyl)oxy]pyrrolidine-2,5-dione

Base Information

Chemical Name:1-[(2-Fluorobenzoyl)oxy]pyrrolidine-2,5-dione
CAS No.:110920-18-8
Molecular Formula:C11H8FNO4
Molecular Weight:237.187
Hs Code.:
DSSTox Substance ID:DTXSID40551965
Nikkaji Number:J428.418F
Wikidata:Q82431895
Mol file:110920-18-8.mol

Synonyms:110920-18-8;1-[(2-Fluorobenzoyl)oxy]pyrrolidine-2,5-dione;(2,5-dioxopyrrolidin-1-yl) 2-fluorobenzoate;2,5-Pyrrolidinedione, 1-[(2-fluorobenzoyl)oxy]-;2,5-dioxopyrrolidin-1-yl 2-fluorobenzoate;succinimidyl fluorobenzoate;SCHEMBL317739;DTXSID40551965;AKOS022061287;A1-24610

Suppliers and Price of 1-[(2-Fluorobenzoyl)oxy]pyrrolidine-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 1-[(2-Fluorobenzoyl)oxy]pyrrolidine-2,5-dione

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:237.04373590
Heavy Atom Count:17
Complexity:341

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)N(C1=O)OC(=O)C2=CC=CC=C2F

Technology Process of 1-[(2-Fluorobenzoyl)oxy]pyrrolidine-2,5-dione

There total 3 articles about 1-[(2-Fluorobenzoyl)oxy]pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 445-29-4
o-fluoro-benzoic acid

: 110920-18-8
2,5-dioxopyrrolidin-1-yl 2-fluorobenzoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.joc.0c01182

Reference yield: 82.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 446-52-6
2-Fluorobenzaldehyde

: 110920-18-8
2,5-dioxopyrrolidin-1-yl 2-fluorobenzoate

Guidance literature:: With oxygen; In acetonitrile; at 80 ℃; for 10h; Green chemistry;
DOI:10.1016/j.tetlet.2017.03.064

Reference yield: 76.0%

: 1072-85-1
o-fluorobromobenzene

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 201230-82-2
carbon monoxide

: 110920-18-8
2,5-dioxopyrrolidin-1-yl 2-fluorobenzoate

Guidance literature:: With N-Methyldicyclohexylamine; [{Pd(cinnamyl)Cl}2]; 9-methyl-9H-fluorene-9-carbonyl chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; toluene; at 95 ℃; for 16h; Sealed tube; Glovebox; Inert atmosphere;
DOI:10.1021/jo5025464