ART-CHEM-BB B018354

Base Information

• Chemical Name: ART-CHEM-BB B018354
• CAS No.: 110932-40-6
• Molecular Formula: C16H11NOS2
• Molecular Weight: 297.39500
• Hs Code.: 2934100090
• Mol file: 110932-40-6.mol

Synonyms:(5E)-5-[(4-phenylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one;

Chemical Property of ART-CHEM-BB B018354

Chemical Property:

• PKA: 7.59±0.30(Predicted)
• PSA: 93.53000
• Density: 1.39g/cm3
• LogP: 3.68930

Purity/Quality:

98%min ^*data from raw suppliers

(5E)-5-(Biphenyl-4-ylmethylene)-2-mercapto-1,3-thiazol-4(5H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ART-CHEM-BB B018354

There total 2 articles about ART-CHEM-BB B018354 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-thioxo-4-thiazolidinone (141-84-4) + 4-Phenylbenzaldehyde (3218-36-8) → 5-(4-phenylbenzylidene)-2-thioxothiazolidin-4-one (110932-40-6)

Guidance literature:

With piperidine; In ethanol; for 18h; Reflux;

DOI:10.1021/ml200284s

Reference yield:

→ 5-(4-phenylbenzylidene)-2-thioxothiazolidin-4-one (110932-40-6)

Guidance literature:

Aus /BRN= 606693/ u. /BRN= 110701/;

Reference yield:

5-(4-phenylbenzylidene)-2-thioxothiazolidin-4-one (110932-40-6) + methyl iodide (74-88-4) → C17H13NOS2

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 20 ℃;

DOI:10.1016/j.bmc.2015.04.065

upstream raw materials:

2-thioxo-4-thiazolidinone

4-Phenylbenzaldehyde

Refernces

• 1、 Robertson, Mark J.,Hadzic, Gordana,Ambrus, Joseph,Pome, D. Yuri,Hyde, Emily,Whiting, Ainslie,Mariana, Anna,Von Kleist, Lisa,Chau, Ngoc,Haucke, Volker,Robinson, Phillip J.,McCluskey, Adam. "The Rhodadyns, a new class of small molecule inhibitors of dynamin gtpase activity". supporting information; experimental part. p. 352 - 356. Retrieved 2012/06/30.