9-(4-Fluoro-5-O-sulfamoyl-α-L-lyxofuranosyl)adenin

Base Information

Chemical Name:9-(4-Fluoro-5-O-sulfamoyl-α-L-lyxofuranosyl)adenin
CAS No.:60102-28-5
Molecular Formula:C₁₀H₁₃FN₆O₆S
Molecular Weight:364.314
Hs Code.:

Synonyms:

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Chemical Property of 9-(4-Fluoro-5-O-sulfamoyl-α-L-lyxofuranosyl)adenin

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Technology Process of 9-(4-Fluoro-5-O-sulfamoyl-α-L-lyxofuranosyl)adenin

There total 13 articles about 9-(4-Fluoro-5-O-sulfamoyl-α-L-lyxofuranosyl)adenin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59996-36-0
N⁶,N⁶-dibenzoyl-9-(5-deoxy-2,3-O-isopropylidene-β-D-erythropent-4-enofuranosyl)adenine

: 24751-69-7,60102-28-5
Nucleocidin

Guidance literature:: Multi-step reaction with 4 steps

1: silver fluoride, iodine / acetonitrile / -40 °C

2: ammonia / methanol / 1 h / Ambient temperature

3: 40 percent / KO₂, 18-crown-6 / tetrahydrofuran; dimethylsulfoxide / 48 h / Ambient temperature

4: 1.) hexabutyldistannoxane, 2.) sulfamoyl chloride / 1.) benzene, reflux, 2 h, 2.) Et₂O, 10 min

With 18-crown-6 ether; sulphamoyl chloride; ammonia; iodine; silver fluoride; bis(tri-n-butyltin)oxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 33962-29-7
N-(9-((3aR,4R,6aS)-2,2-dimethyl-6-methylenetetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)benzamide

: 24751-69-7,60102-28-5
Nucleocidin

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / pyridine / 3 h / 0 °C

2: silver fluoride, iodine / acetonitrile / -40 °C

3: ammonia / methanol / 1 h / Ambient temperature

4: 40 percent / KO₂, 18-crown-6 / tetrahydrofuran; dimethylsulfoxide / 48 h / Ambient temperature

5: 1.) hexabutyldistannoxane, 2.) sulfamoyl chloride / 1.) benzene, reflux, 2 h, 2.) Et₂O, 10 min

With 18-crown-6 ether; sulphamoyl chloride; ammonia; iodine; silver fluoride; bis(tri-n-butyltin)oxide; In tetrahydrofuran; pyridine; methanol; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 40653-96-1
N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-methylsulfonyladenosine

: 24751-69-7,60102-28-5
Nucleocidin

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / t-BuOK / tetrahydrofuran / 3 h / -78 °C

2: 67 percent / pyridine / 3 h / 0 °C

3: silver fluoride, iodine / acetonitrile / -40 °C

4: ammonia / methanol / 1 h / Ambient temperature

5: 40 percent / KO₂, 18-crown-6 / tetrahydrofuran; dimethylsulfoxide / 48 h / Ambient temperature

6: 1.) hexabutyldistannoxane, 2.) sulfamoyl chloride / 1.) benzene, reflux, 2 h, 2.) Et₂O, 10 min

With 18-crown-6 ether; sulphamoyl chloride; potassium tert-butylate; ammonia; iodine; silver fluoride; bis(tri-n-butyltin)oxide; In tetrahydrofuran; pyridine; methanol; dimethyl sulfoxide; acetonitrile;