33962-29-7

Upstream product

• 40653-96-1 N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-methylsulfonyladenosine 
• 4546-55-8 N-benzoyladenosine 
• 39947-05-2 ((3aR,4R,6R,6aR)-6-(6-benzamido-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl 4-methylbenzenesulfonate 
• 39947-04-1 N-6-benzoyl-2',3'-O-isopropylideneadenosine 
• 98-88-4 benzoyl chloride 
• 362-75-4 2',3'-isopropylidene adenosine 

Downstream Products

• 152387-33-2 N-[9-((3aR,4R,6aS)-2,2-Dimethyl-6-oxo-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide 
• 151725-74-5 5'-deoxy-4'-fluoro-5'-iodo-2',3'-O-isopropylideneadenosine 
• 151725-74-5 9-((3aR,4R,6S,6aS)-6-Fluoro-6-iodomethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine 
• 24751-69-7 Nucleocidin 
• 59996-37-1 N⁶,N⁶-dibenzoyl-5'-deoxy-4'-fluoro-5'-iodo-2',3'-O-isopropylideneadenosine 
• 59996-37-1 N⁶,N⁶-dibenzoyl-9-(5-deoxy-4-fluoro-5-iodo-2,3-O-isopropylidene-α-L-lyxofuranosyl)adenine 
• 33962-34-4 5'-azido-5'-deoxy-4'-fluoro-2',3'-O-isopropylideneadenosine 
• 59996-36-0 N⁶,N⁶-dibenzoyl-9-(5-deoxy-2,3-O-isopropylidene-β-D-erythropent-4-enofuranosyl)adenine 
• 40656-23-3 (4S)-N-benzoyl-4-bromomethyl-5-formyl-2,2-dimethyl-(3at,10at)-4,5,10,10a-tetrahydro-3aH-4r,10c-epioxido-[1,3]dioxolo[4,5-e]imidazo[1,5-a][1,3]diazepine-6-carboximidic acid amide 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS OF MODULATING THE IMMUNE RESPONSE BY ACTIVATING ALPHA PROTEIN KINASE 1

The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.

Synthetic Approaches towards Nucleocidin and Selected Analogues; anti-HIV Activity in 4'-Fluorinated Nucleoside Derivatives

Nucleocidin 1 has been synthesised from the adenosine derivative 4 via the intermediacy of the dihalogeno compound 9.The latter compound showed slight but significant activity against HIV-infected cells while the isomer 10 and the monohalogeno compound 60 were inactive.Synthetic approaches towards other 4'-fluorinated nucleoside derivatives are also described.The epimeric 4'-fluorinated nucleosides 26 and 27 displayed similar activity against HIV-infected cells to that observed for the dihalogenated compound 9.

Ozonolysis of 6-N-Benzoyl-9-(5-deoxy-2,3-O-isopropylidene-β-D-erythro-pent-4-enofuranosyl)adenine and Relateds Compounds

The nucleoside 4',5'-olefins 3, 5, 7 and 9 are readily converted into the corresponding lactones 4, 6, 8 and 10, respectively, by ozonolysis in dichloromethane solution at -78 deg C.