Technology Process of (2R,4R)-1-hydroxy-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentan-3-one
There total 3 articles about (2R,4R)-1-hydroxy-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentan-3-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-1-((4-methoxybenzyl)oxy)-2-methylpentan-3-one;
With
dicyclohexylboron chloride; triethylamine;
In
diethyl ether;
at 0 ℃;
for 2h;
Inert atmosphere;
formaldehyd;
In
diethyl ether;
at -78 - 0 ℃;
Overall yield = 100%; Overall yield = 1.10 g; diastereoselective reaction;
Inert atmosphere;
DOI:10.1021/jo401293a
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / -20 - 0 °C / Inert atmosphere
2.1: tetrahydrofuran / 0.83 h / 0 °C / Inert atmosphere
3.1: titanium tetrachloride; titanium(IV) isopropylate / dichloromethane / 0.03 h / -78 °C / Inert atmosphere
3.2: 0.5 h / -78 °C / Inert atmosphere
3.3: 1.5 h / -78 °C / Inert atmosphere
With
titanium(IV) isopropylate; isopropylmagnesium chloride; titanium tetrachloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo401293a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 0.83 h / 0 °C / Inert atmosphere
2.1: titanium tetrachloride; titanium(IV) isopropylate / dichloromethane / 0.03 h / -78 °C / Inert atmosphere
2.2: 0.5 h / -78 °C / Inert atmosphere
2.3: 1.5 h / -78 °C / Inert atmosphere
With
titanium(IV) isopropylate; titanium tetrachloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo401293a
