(R)-(+)-5-bromo-2-hydroxypentanenitrile

Base Information

Chemical Name:(R)-(+)-5-bromo-2-hydroxypentanenitrile
CAS No.:164472-76-8
Molecular Formula:C₅H₈BrNO
Molecular Weight:178.029
Hs Code.:

Synonyms:

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Chemical Property of (R)-(+)-5-bromo-2-hydroxypentanenitrile

Chemical Property:

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Technology Process of (R)-(+)-5-bromo-2-hydroxypentanenitrile

There total 1 articles about (R)-(+)-5-bromo-2-hydroxypentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38694-47-2
4-bromobutyraldehyde

: 4111-12-0
(+/-)-2-methyl-2-hydroxyhexanenitrile

: 135415-89-3
(R)-2-hydroxy-2-methylhexanenitrile

: (S)-4-bromo-1-cyanobutyl alcohol

: 164472-76-8
(R)-(+)-5-bromo-2-hydroxypentanenitrile

: (S)-2-hydroxy-2-methylhexanenitrile

Guidance literature:: With crude extract of almond containing (R)-oxynitrilase; In di-isopropyl ether; for 12h; Product distribution; var. of cyanohydrin, ratio;
DOI:10.1039/c39950000989

Reference yield:

: 164472-76-8
(R)-(+)-5-bromo-2-hydroxypentanenitrile

: (2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(4-fluoro-phenyl)-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / imidazole; DMAP / CH₂Cl₂ / 24 h / 20 °C

2: tetrahydrofuran / 5 h / Heating

3: NaBH₄ / methanol / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0957-4166(01)00080-5

Reference yield:

: 164472-76-8
(R)-(+)-5-bromo-2-hydroxypentanenitrile

: 349132-12-3
(R,R)-1-(benzyloxycarbonyl)-3-tert-butyldimethylsilyloxy-2-(p-fluorophenyl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / imidazole; DMAP / CH₂Cl₂ / 24 h / 20 °C

2: tetrahydrofuran / 5 h / Heating

3: NaBH₄ / methanol / 20 °C

4: aq. Na₂CO₃ / CH₂Cl₂ / 4 h / 0 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; sodium carbonate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0957-4166(01)00080-5