5-exo-acetoxy-2-endo-benzoylamino norbornane

Base Information

• Chemical Name: 5-exo-acetoxy-2-endo-benzoylamino norbornane
• CAS No.: 111013-45-7
• Molecular Formula: C₁₆H₁₉NO₃
• Molecular Weight: 273.332
• Mol file: 111013-45-7.mol

Synonyms:

Chemical Property of 5-exo-acetoxy-2-endo-benzoylamino norbornane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-exo-acetoxy-2-endo-benzoylamino norbornane

There total 8 articles about 5-exo-acetoxy-2-endo-benzoylamino norbornane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

acetic anhydride (108-24-7) + N-((1S,2R,4S,5R)-5-Hydroxy-bicyclo[2.2.1]hept-2-yl)-benzamide (105512-48-9,105617-10-5,111058-87-8,111058-88-9,122088-17-9) → 5-exo-acetoxy-2-exo-benzoylamino norbornane (111013-45-7,111058-93-6)

Guidance literature:

With pyridine;

DOI:10.1016/S0040-4020(01)86811-3

Reference yield:

exo-2-aminonorbornane (7242-92-4) → 5-exo-acetoxy-2-exo-benzoylamino norbornane (111013-45-7,111058-93-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / triethylamine / diethyl ether / 0 °C

2: 35 percent / H₂O / with culture of the Beauveria sulfurescens

3: 90 percent / pyridine

With pyridine; triethylamine; In diethyl ether; water;

DOI:10.1016/S0040-4020(01)86811-3

Reference yield:

bicyclo[2.2.1]heptan-2-endo-amine hydrochloride (65481-69-8) → 5-exo-acetoxy-2-endo-benzoylamino norbornane (111013-45-7,111058-93-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / 1 N NaOH / diethyl ether / Ambient temperature

2: 30 percent / sodium dodecyl benzenesulfonate / H₂O / with culture of the Beauveria sulfurescens

3: pyridine

With pyridine; sodium hydroxide; sodium dodecylbenzenesulfonate; In diethyl ether; water;

DOI:10.1016/S0040-4020(01)86811-3

upstream raw materials:

acetic anhydride

N-((1S,2R,4S,5R)-5-Hydroxy-bicyclo[2.2.1]hept-2-yl)-benzamide

exo-2-aminonorbornane

benzoyl chloride