Bis-(2-chloro-ethyl)-((3aR,4R,5aR,8R,9aR,9bS)-4-octyloxy-2-oxo-8-phenyl-octahydro-1,5,7,9-tetraoxa-3-aza-2λ⁵-phospha-cyclopenta[a]naphthalen-2-yl)-amine

Base Information

• Chemical Name: Bis-(2-chloro-ethyl)-((3aR,4R,5aR,8R,9aR,9bS)-4-octyloxy-2-oxo-8-phenyl-octahydro-1,5,7,9-tetraoxa-3-aza-2λ⁵-phospha-cyclopenta[a]naphthalen-2-yl)-amine
• CAS No.: 211567-34-9
• Molecular Formula: C₂₅H₃₉Cl₂N₂O₆P
• Molecular Weight: 565.474

Synonyms:

Chemical Property of Bis-(2-chloro-ethyl)-((3aR,4R,5aR,8R,9aR,9bS)-4-octyloxy-2-oxo-8-phenyl-octahydro-1,5,7,9-tetraoxa-3-aza-2λ⁵-phospha-cyclopenta[a]naphthalen-2-yl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bis-(2-chloro-ethyl)-((3aR,4R,5aR,8R,9aR,9bS)-4-octyloxy-2-oxo-8-phenyl-octahydro-1,5,7,9-tetraoxa-3-aza-2λ⁵-phospha-cyclopenta[a]naphthalen-2-yl)-amine

There total 8 articles about Bis-(2-chloro-ethyl)-((3aR,4R,5aR,8R,9aR,9bS)-4-octyloxy-2-oxo-8-phenyl-octahydro-1,5,7,9-tetraoxa-3-aza-2λ⁵-phospha-cyclopenta[a]naphthalen-2-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N,N-di(2-chloroethyl)amidophosphoric acid dichloride (127-88-8) + 1-octyl 2-amino-4,6-O-benzylidene-2-deoxy-β-D-allopyranoside (211567-31-6) → Bis-(2-chloro-ethyl)-((3aR,4R,5aR,8R,9aR,9bS)-4-octyloxy-2-oxo-8-phenyl-octahydro-1,5,7,9-tetraoxa-3-aza-2λ5-phospha-cyclopenta[a]naphthalen-2-yl)-amine (211567-34-9)

Guidance literature:

In dichloromethane; 0 deg C, then room temp., overnight;

DOI:10.1016/S0008-6215(98)00056-1

Reference yield:

octanol (111-87-5) → Bis-(2-chloro-ethyl)-((3aR,4R,5aR,8R,9aR,9bS)-4-octyloxy-2-oxo-8-phenyl-octahydro-1,5,7,9-tetraoxa-3-aza-2λ5-phospha-cyclopenta[a]naphthalen-2-yl)-amine (211567-34-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 80 percent / 4 Angstroem mol sieves, Hg(CN)2 / nitromethane; toluene / Ambient temperature

2: NaOMe / methanol / 30 h / Ambient temperature

3: ZnCl₂

4: 71 percent / pyridine / 24 h / 0 °C

5: 78 percent / anh. NaOAc / 2-methoxy-ethanol; H₂O / 12 h / Heating

6: 88 percent / KOH / aq. ethanol / 6 h / Heating

7: 85 percent / CH₂Cl₂ / 0 deg C, then room temp., overnight

With pyridine; potassium hydroxide; 4 A molecular sieve; sodium methylate; sodium acetate; mercury(II) cyanide; zinc(II) chloride; In methanol; nitromethane; ethanol; dichloromethane; 2-methoxy-ethanol; water; toluene;

DOI:10.1016/S0008-6215(98)00056-1

Reference yield:

octyl 2-(acetylamino)-2-deoxy-β-D-glucopyranoside (147126-58-7,383417-49-0) → Bis-(2-chloro-ethyl)-((3aR,4R,5aR,8R,9aR,9bS)-4-octyloxy-2-oxo-8-phenyl-octahydro-1,5,7,9-tetraoxa-3-aza-2λ5-phospha-cyclopenta[a]naphthalen-2-yl)-amine (211567-34-9)

Guidance literature:

Multi-step reaction with 5 steps

1: ZnCl₂

2: 71 percent / pyridine / 24 h / 0 °C

3: 78 percent / anh. NaOAc / 2-methoxy-ethanol; H₂O / 12 h / Heating

4: 88 percent / KOH / aq. ethanol / 6 h / Heating

5: 85 percent / CH₂Cl₂ / 0 deg C, then room temp., overnight

With pyridine; potassium hydroxide; sodium acetate; zinc(II) chloride; In ethanol; dichloromethane; 2-methoxy-ethanol; water;

DOI:10.1016/S0008-6215(98)00056-1

upstream raw materials:

N,N-di(2-chloroethyl)amidophosphoric acid dichloride

1-octyl 2-amino-4,6-O-benzylidene-2-deoxy-β-D-allopyranoside

octanol

octyl 2-(acetylamino)-2-deoxy-β-D-glucopyranoside

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 211567-34-9 Bis-(2-chloro-ethyl)-((3aR,4R,5aR,8R,9aR,9bS)-4-octyloxy-2-oxo-8-phenyl-octahydro-1,5,7,9-tetraoxa-3-aza-2λ⁵-phospha-cyclopenta[a]naphthalen-2-yl)-amine

Send

Send

Metric Ton KG G Pound L ML

Send

Send