74233-03-7Relevant academic research and scientific papers
Synthesis of Chiral Piperazines via Hydrogenation of Pyrazines Activated by Alkyl Halides
Huang, Wen-Xue,Liu, Lian-Jin,Wu, Bo,Feng, Guang-Shou,Wang, Baomin,Zhou, Yong-Gui
supporting information, p. 3082 - 3085 (2016/07/13)
A facile method has been developed for the synthesis of chiral piperazines through Ir-catalyzed hydrogenation of pyrazines activated by alkyl halides, giving a wide range of chiral piperazines including 3-substituted as well as 2,3- and 3,5-disubstituted
Supporting ligand-assisted N-heterocyclic carbene palladium complexes: Characterization, computation, and catalytic activity in Suzuki-Miyaura cross coupling between aryl and heteroaromatic chlorides and various boronic acids
Shen, An,Hu, Yu-Cai,Liu, Ting-Ting,Ni, Chen,Luo, Yong,Cao, Yu-Cai
supporting information, p. 2055 - 2058 (2016/04/26)
A new series of imine-Pd-(N-heterocyclic carbene) complexes have been developed as efficient catalysts for Pd-catalyzed Suzuki-Miyaura coupling reaction. Based on the performance of supporting ligands, correlation of structure and catalytic activity has been demonstrated via experimental and computational modeling. A broad reaction scope of aryl and heteroaromatic chlorides could proceed at extremely low catalyst loading (minimum 0.005 mol %).
Synthesis of pyridines and pyrazines using an intramolecular hydroamination-based reaction sequence
Rizk, Toni,Bilodeau, Eric J.-F.,Beauchemin, Andre M.
supporting information; experimental part, p. 8325 - 8327 (2010/01/16)
A management issue! Various pyridines and pyrazines can be efficiently accessed from simple acyclic precursors using an intramolecular hydroamination/isomerization/aromatization sequence (see scheme). ρ-Toluenesulfonic acid (2 mol%) is used to catalyze this novel alkyne annulation, in which the oxime group allows for a subsequent redoxneutral aromatization step to occur.
Reactions of the Monoxides of 2,6-Disubstituted Pyrazines with Phosphoryl Chloride and Acetic Anhydride
Ohta, Akihiro,Imazeki, Akiko,Itoigawa, Yohko,Yamada, Hiroko,Suga, Chieko,et al.
, p. 311 - 320 (2007/10/02)
The monoxides of 2,6-dimethyl- (1), 2,6-diphenyl- (2), and 2-methyl-6-phenylpyrazines (3) were subjected to the reactions with phosphoryl chloride and acetic anhydride.Some reactions of the chloropyrazines and hydroxypyrazines obtained thus were also inve
Reactions of organolithium-diazine adducts and dihydrodiazines with electrophilic reagents
Stoel, R. E. van der,Plas, H. C. van der,Jongejan, H.,Hoeve, L.
, p. 234 - 238 (2007/10/02)
Some organolithium-diazine adducts and some dihydropyrimidines were treated with electrophilic reagents.Both 4,6-diphenyl-1(3)-lithio-1,4(3,4)-dihydropyrimidine and 4,6-diphenyl-1,4(3,4)-dihydropyrimidine were attacked by the electrophilic reagent methyl
