Methyl-phosphonic acid benzotriazol-1-yl ester (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Methyl-phosphonic acid benzotriazol-1-yl ester (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester
• CAS No.: 116872-52-7
• Molecular Formula: C₂₉H₃₇N₆O₇PSi
• Molecular Weight: 640.708

Synonyms:

Chemical Property of Methyl-phosphonic acid benzotriazol-1-yl ester (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of Methyl-phosphonic acid benzotriazol-1-yl ester (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester

There total 4 articles about Methyl-phosphonic acid benzotriazol-1-yl ester (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzotriazol-1-ol (2592-95-2) → Methyl-phosphonic acid benzotriazol-1-yl ester (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester (116872-52-7,116887-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 8 h / Ambient temperature

2: dioxane / 1 h / Ambient temperature

With pyridine; In 1,4-dioxane;

DOI:10.1016/S0040-4039(00)80262-2

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → Methyl-phosphonic acid benzotriazol-1-yl ester (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester (116872-52-7,116887-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 76.5 percent / imidazole / pyridine

2: dioxane / 1 h / Ambient temperature

With 1H-imidazole; In 1,4-dioxane; pyridine;

DOI:10.1016/S0040-4039(00)80262-2

Reference yield:

N4-benzoyl-2'-deoxycytidine (4836-13-9) → Methyl-phosphonic acid benzotriazol-1-yl ester (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester (116872-52-7,116887-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 76.5 percent / imidazole / pyridine

2: dioxane / 1 h / Ambient temperature

With 1H-imidazole; In 1,4-dioxane; pyridine;

DOI:10.1016/S0040-4039(00)80262-2

upstream raw materials:

O,O-bis(benzotriazol-1-yl)methylphosphonate

N-(1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

benzotriazol-1-ol

tert-butyldimethylsilyl chloride

Downstream raw materials:

5'-O-t-butyldimethylsilyl N⁴-benzoyldeoxycytidine 3'-O(S-benzyl)methylphosphonothioate

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