2-<(4-bromo-2-fluorophenyl)methyl>-4'-(methoxycarbonyl)spiro-2'5'-dione 1,1-dioxide

Base Information

Chemical Name:2-<(4-bromo-2-fluorophenyl)methyl>-4'-(methoxycarbonyl)spiro-2'5'-dione 1,1-dioxide
CAS No.:145020-73-1
Molecular Formula:C₁₉H₁₄BrFN₂O₆S
Molecular Weight:497.298
Hs Code.:

2-<(4-bromo-2-fluorophenyl)methyl>-4'-(methoxycarbonyl)spiro<benziisothiazole-3,3'-pyrrolidine>-2'5'-dione 1,1-dioxide

Synonyms:

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Chemical Property of 2-<(4-bromo-2-fluorophenyl)methyl>-4'-(methoxycarbonyl)spiro-2'5'-dione 1,1-dioxide

Chemical Property:

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Technology Process of 2-<(4-bromo-2-fluorophenyl)methyl>-4'-(methoxycarbonyl)spiro-2'5'-dione 1,1-dioxide

There total 6 articles about 2-<(4-bromo-2-fluorophenyl)methyl>-4'-(methoxycarbonyl)spiro-2'5'-dione 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128-44-9
saccharin sodium salt

: 145020-73-1
2-<(4-bromo-2-fluorophenyl)methyl>-4'-(methoxycarbonyl)spiro-2'5'-dione 1,1-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / dimethylformamide / 1 h / 100 °C

2: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

3: 73 percent / acetic anhydride / 0.83 h / Heating

4: 68 percent / dimethylsulfoxide / 1.42 h / Ambient temperature

5: 1.) hydrogen chloride / 1.) RT, 5 d, 2.) reflux, 4 h

With hydrogenchloride; potassium tert-butylate; acetic anhydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00102a016

Reference yield:

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 145020-73-1
2-<(4-bromo-2-fluorophenyl)methyl>-4'-(methoxycarbonyl)spiro-2'5'-dione 1,1-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / dimethylformamide / 1 h / 100 °C

2: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

3: 73 percent / acetic anhydride / 0.83 h / Heating

4: 68 percent / dimethylsulfoxide / 1.42 h / Ambient temperature

5: 1.) hydrogen chloride / 1.) RT, 5 d, 2.) reflux, 4 h

With hydrogenchloride; potassium tert-butylate; acetic anhydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00102a016

Reference yield:

: 127511-40-4
2-<(4-bromo-2-fluorophenyl)methyl>benzoisothiazolin-3-one 1,1-dioxide

: 145020-73-1
2-<(4-bromo-2-fluorophenyl)methyl>-4'-(methoxycarbonyl)spiro-2'5'-dione 1,1-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

2: 73 percent / acetic anhydride / 0.83 h / Heating

3: 68 percent / dimethylsulfoxide / 1.42 h / Ambient temperature

4: 1.) hydrogen chloride / 1.) RT, 5 d, 2.) reflux, 4 h

With hydrogenchloride; potassium tert-butylate; acetic anhydride; In dimethyl sulfoxide;
DOI:10.1021/jm00102a016