3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-tert-butoxycarbonylamino-3-phenyl-cyclobutanecarboxylic acid

Base Information

• Chemical Name: 3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-tert-butoxycarbonylamino-3-phenyl-cyclobutanecarboxylic acid
• CAS No.: 606137-92-2
• Molecular Formula: C₂₇H₂₉F₆NO₅
• Molecular Weight: 561.521

Synonyms:

Chemical Property of 3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-tert-butoxycarbonylamino-3-phenyl-cyclobutanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-tert-butoxycarbonylamino-3-phenyl-cyclobutanecarboxylic acid

There total 8 articles about 3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-tert-butoxycarbonylamino-3-phenyl-cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-6,8-dioxo-2-phenyl-5,7-diaza-spiro[3.4]octane-5,7-dicarboxylic acid di-tert-butyl ester → 3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-tert-butoxycarbonylamino-3-phenyl-cyclobutanecarboxylic acid (606137-92-2)

Guidance literature:

2-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-6,8-dioxo-2-phenyl-5,7-diaza-spiro[3.4]octane-5,7-dicarboxylic acid di-tert-butyl ester; With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

With di-tert-butyl dicarbonate; sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2006.04.031

Reference yield:

2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethanone (530441-99-7) → 3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-tert-butoxycarbonylamino-3-phenyl-cyclobutanecarboxylic acid (606137-92-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 92 percent / NaNH₂ / tetrahydrofuran / 24 h / 20 °C

2.1: 86 percent / Zn-Cu / diethyl ether; 1,2-dimethoxy-ethane / 120 h / Heating

3.1: Zn dust; AcOH / 48 h / 20 °C

4.1: 46 percent / H₂O / ethanol / 36 h / 90 °C

5.1: DMAP / tetrahydrofuran / 3 h / 20 °C

6.1: aq. LiOH / tetrahydrofuran / 2 h / 20 °C

6.2: (Boc)2O; aq. NaHCO₃ / tetrahydrofuran / 24 h / 20 °C

With dmap; lithium hydroxide; water; copper; sodium amide; acetic acid; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; 1.1: Wittig reaction;

DOI:10.1016/j.bmcl.2006.04.031

Reference yield:

1-[(R)-1-(2-Phenyl-allyloxy)-ethyl]-3,5-bis-trifluoromethyl-benzene (606137-78-4) → 3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-tert-butoxycarbonylamino-3-phenyl-cyclobutanecarboxylic acid (606137-92-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 86 percent / Zn-Cu / diethyl ether; 1,2-dimethoxy-ethane / 120 h / Heating

2.1: Zn dust; AcOH / 48 h / 20 °C

3.1: 46 percent / H₂O / ethanol / 36 h / 90 °C

4.1: DMAP / tetrahydrofuran / 3 h / 20 °C

5.1: aq. LiOH / tetrahydrofuran / 2 h / 20 °C

5.2: (Boc)2O; aq. NaHCO₃ / tetrahydrofuran / 24 h / 20 °C

With dmap; lithium hydroxide; water; copper; acetic acid; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol;

DOI:10.1016/j.bmcl.2006.04.031

upstream raw materials:

2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethanone

1-[(R)-1-(2-Phenyl-allyloxy)-ethyl]-3,5-bis-trifluoromethyl-benzene

3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutanone

3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2,2-dichloro-3-phenyl-cyclobutanone

Downstream raw materials:

{3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-dimethylcarbamoyl-3-phenyl-cyclobutyl}-carbamic acid tert-butyl ester

{3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-methylcarbamoyl-3-phenyl-cyclobutyl}-carbamic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 606137-92-2 3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-tert-butoxycarbonylamino-3-phenyl-cyclobutanecarboxylic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send