3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2,2-dichloro-3-phenyl-cyclobutanone

Base Information

Chemical Name:3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2,2-dichloro-3-phenyl-cyclobutanone
CAS No.:903877-33-8
Molecular Formula:C₂₁H₁₆Cl₂F₆O₂
Molecular Weight:485.253
Hs Code.:

Synonyms:3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2,2-dichloro-3-phenyl-cyclobutanone

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Chemical Property of 3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2,2-dichloro-3-phenyl-cyclobutanone

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Technology Process of 3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2,2-dichloro-3-phenyl-cyclobutanone

There total 4 articles about 3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2,2-dichloro-3-phenyl-cyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 606137-78-4
1-[(R)-1-(2-Phenyl-allyloxy)-ethyl]-3,5-bis-trifluoromethyl-benzene

: 76-02-8
trifluoroacetyl chloride

: 903877-33-8
3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2,2-dichloro-3-phenyl-cyclobutanone

Guidance literature:: With copper; zinc; In 1,2-dimethoxyethane; diethyl ether; for 120h; Heating;
DOI:10.1016/j.bmcl.2006.04.031

Reference yield:

: 530441-99-7
2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethanone

: 903877-33-8
3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2,2-dichloro-3-phenyl-cyclobutanone

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NaNH₂ / tetrahydrofuran / 24 h / 20 °C

2: 86 percent / Zn-Cu / diethyl ether; 1,2-dimethoxy-ethane / 120 h / Heating

With copper; sodium amide; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; 1: Wittig reaction;
DOI:10.1016/j.bmcl.2006.04.031

Reference yield:

: 62861-51-2
phenacyl trifluoromethanesulfonate

: 903877-33-8
3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2,2-dichloro-3-phenyl-cyclobutanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1,2-dichloro-ethane / 4 h / 80 °C

2: 92 percent / NaNH₂ / tetrahydrofuran / 24 h / 20 °C

3: 86 percent / Zn-Cu / diethyl ether; 1,2-dimethoxy-ethane / 120 h / Heating

With copper; sodium amide; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; 1,2-dichloro-ethane; 2: Wittig reaction;
DOI:10.1016/j.bmcl.2006.04.031