2,6-Bis(1-methyl-1H-benzo[d]imidazol-2-yl)pyridine

Base Information

• Chemical Name: 2,6-Bis(1-methyl-1H-benzo[d]imidazol-2-yl)pyridine
• CAS No.: 112362-30-8
• Molecular Formula: C21H17N5
• Molecular Weight: 339.399
• Hs Code.: 2933990090
• ChEMBL ID: CHEMBL3792522
• DSSTox Substance ID: DTXSID60477138
• Nikkaji Number: J690.041K
• Wikidata: Q82309377
• Mol file: 112362-30-8.mol

Synonyms:2,6-B-MBIP;2,6-bis(N-methylbenzimidazol-2-yl)pyridine

Chemical Property of 2,6-Bis(1-methyl-1H-benzo[d]imidazol-2-yl)pyridine

Chemical Property:

• PSA: 48.53000
• LogP: 4.18900
• Storage Temp.: 2-8°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 339.14839556
• Heavy Atom Count: 26
• Complexity: 457

Purity/Quality:

99% ^*data from raw suppliers

2,6-Bis(1-methyl-1H-benzo[d]imidazol-2-yl)pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=CC=CC=C2N=C1C3=NC(=CC=C3)C4=NC5=CC=CC=C5N4C

Technology Process of 2,6-Bis(1-methyl-1H-benzo[d]imidazol-2-yl)pyridine

There total 7 articles about 2,6-Bis(1-methyl-1H-benzo[d]imidazol-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Pyridine-2,6-dicarboxylic acid (499-83-2) + N-methyl-1,2-phenylenediamine (4760-34-3) → 2,6-bis(1-methyl-1H-benzo[d]imidazol-2-yl)pyridine (112362-30-8)

Guidance literature:

With polyphosphoric acid; at 210 ℃; for 4h; Neat (no solvent);

DOI:10.1021/ic2016885

Reference yield: 82.0%

2,6-bis(benzimidazole-2'-yl)pyridine (28020-73-7) + methyl iodide (74-88-4) → 2,6-bis(1-methyl-1H-benzo[d]imidazol-2-yl)pyridine (112362-30-8)

Guidance literature:

2,6-bis(benzimidazole-2'-yl)pyridine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1002/chem.201802277

Reference yield: 58.0%

2,6-bis(benzimidazole-2'-yl)pyridine (28020-73-7) → 2,6-bis(1-methyl-1H-benzo[d]imidazol-2-yl)pyridine (112362-30-8)

Guidance literature:

With potassium; In tetrahydrofuran; for 1h; Inert atmosphere; Reflux;

upstream raw materials:

Pyridine-2,6-dicarboxylic acid

N-methylbenzene-1,2-diamine dihydrochloride

2,6-bis(benzimidazole-2'-yl)pyridine

methyl iodide

Downstream raw materials:

{chloro-copper(II)(mbzimpy)}perchlorate*H₂O

tetraethylammonium perchlorate