[4-({1-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-methoxy)-phenoxy]-acetic acid tert-butyl ester

Base Information

• Chemical Name: [4-({1-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-methoxy)-phenoxy]-acetic acid tert-butyl ester
• CAS No.: 437756-14-4
• Molecular Formula: C₄₂H₆₂N₄O₁₀Si
• Molecular Weight: 811.061

Synonyms:

Chemical Property of [4-({1-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-methoxy)-phenoxy]-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-({1-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-methoxy)-phenoxy]-acetic acid tert-butyl ester

There total 8 articles about [4-({1-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-methoxy)-phenoxy]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonyl-L-valyl-L-proline (47450-18-0,68166-40-5,53331-43-4) → [4-({1-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-methoxy)-phenoxy]-acetic acid tert-butyl ester (437756-14-4)

Guidance literature:

Multi-step reaction with 3 steps

1: WSC; pyridine

2: H₂ / Pd(OH)2 / ethyl acetate

3: WSC; pyridine

With pyridine; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium dihydroxide; In ethyl acetate;

DOI:10.1016/S0960-894X(01)00797-1

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → [4-({1-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-methoxy)-phenoxy]-acetic acid tert-butyl ester (437756-14-4)

Guidance literature:

Multi-step reaction with 6 steps

1: DMAP; Et₃N / CH₂Cl₂

2: Des-Martin periodinane / CH₂Cl₂

3: H₂ / Pd(OH)2 / ethyl acetate

4: WSC; pyridine

5: H₂ / Pd(OH)2 / ethyl acetate

6: WSC; pyridine

With pyridine; dmap; hydrogen; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium dihydroxide; In dichloromethane; ethyl acetate;

DOI:10.1016/S0960-894X(01)00797-1

Reference yield:

2-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-3-methyl-butan-1-ol (437756-10-0) → [4-({1-[2-(1-{[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-hydroxy-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-methoxy)-phenoxy]-acetic acid tert-butyl ester (437756-14-4)

Guidance literature:

Multi-step reaction with 3 steps

1: WSC; pyridine

2: H₂ / Pd(OH)2 / ethyl acetate

3: WSC; pyridine

With pyridine; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium dihydroxide; In ethyl acetate;

DOI:10.1016/S0960-894X(01)00797-1

upstream raw materials:

N-benzyloxycarbonyl-L-valyl-L-proline

tert-butyldimethylsilyl chloride

2-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-3-methyl-butan-1-ol

{(S)-1-[Hydroxy-(4-hydroxy-benzooxazol-2-yl)-methyl]-2-methyl-propyl}-carbamic acid benzyl ester

Downstream raw materials:

{4-[((S)-1-{(S)-2-[(S)-1-(4-Hydroxy-benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-methoxy]-phenoxy}-acetic acid tert-butyl ester

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