5-amino-3-[(4-methoxyphenyl)amino]-1H-pyrazole-4-carbonitrile

Base Information

• Chemical Name: 5-amino-3-[(4-methoxyphenyl)amino]-1H-pyrazole-4-carbonitrile
• CAS No.: 112606-39-0
• Molecular Formula: C₁₁H₁₁N₅O
• Molecular Weight: 229.241
• European Community (EC) Number: 898-435-1
• ChEMBL ID: CHEMBL4800613
• Mol file: 112606-39-0.mol

Synonyms:5-amino-3-[(4-methoxyphenyl)amino]-1H-pyrazole-4-carbonitrile;112606-39-0;5-amino-3-(4-methoxyanilino)-1H-pyrazole-4-carbonitrile;1H-Pyrazole-4-carbonitrile, 3-amino-5-[(4-methoxyphenyl)amino]-;488721-72-8;SCHEMBL8123598;CHEMBL4800613;FLMZLZRMLJQFJA-UHFFFAOYSA-N;AKOS001121373;CS-0233840;EN300-13648;5-amino-4-cyano-3-(4-methoxy-phenylamino)-pyrazole;3-amino-5-(p-anisidino)-2H-pyrazole-4-carbonitrile;Z90667803

Chemical Property of 5-amino-3-[(4-methoxyphenyl)amino]-1H-pyrazole-4-carbonitrile

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 229.09635999
• Heavy Atom Count: 17
• Complexity: 294

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NC2=NNC(=C2C#N)N

Technology Process of 5-amino-3-[(4-methoxyphenyl)amino]-1H-pyrazole-4-carbonitrile

There total 7 articles about 5-amino-3-[(4-methoxyphenyl)amino]-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-cyano-3-(4-methoxyphenylamino)-3-methylsulfanylacrylonitrile (85106-72-5) → 5-amino-3-(4-methoxyphenylamino)-1H-pyrazole-4-carbonitrile (112606-39-0,488721-72-8)

Guidance literature:

With hydrazine hydrate; at 100 ℃;

DOI:10.1002/jhet.5570270355

Reference yield: 70.0%

α-Cyano-β-(p-methoxy-anilino)-acrylonitril (21025-61-6) → 5-amino-3-(4-methoxyphenylamino)-1H-pyrazole-4-carbonitrile (112606-39-0,488721-72-8)

Guidance literature:

With hydrazine hydrate;

Reference yield:

4-methoxy-aniline (104-94-9) → 5-amino-3-(4-methoxyphenylamino)-1H-pyrazole-4-carbonitrile (112606-39-0,488721-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / methanol / 15 h / Heating

2: 91 percent / hydrazine monohydrate / dimethylformamide / 6 h / 100 °C

With hydrazine hydrate; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.55.881

upstream raw materials:

2-cyano-3-(4-methoxyphenylamino)-3-methylsulfanylacrylonitrile

[Bis(methylthio)methylene]malononitrile

4-methoxy-aniline

α-Cyano-β-(p-methoxy-anilino)-acrylonitril

Downstream raw materials:

2-(4-methoxyphenylamino)-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

2-(p-anisidino)-6-(2,4-di-O-benzylidene-D-erytronoyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

4-(3-chloro-phenylamino)-3-(4-methoxy-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine

C₁₅H₁₂ClN₅O