6671-70-1

Upstream product

• 1165952-91-9 cyclohexa-1,3-diene 

Downstream Products

• 30182-12-8 4-hydroxy-2-cyclohexenone 
• 53762-85-9 (1S,4R)-Cyclohex-2-ene-1,4-diol 
• 74643-89-3 syn-1,2;3,4-diepoxycyclohexane 
• 67-64-1 acetone 
• 2975-92-0 (+/-)-1D-cyclohexane-1,2,4/3-tetrol 
• 20021-56-1 (+/-)-1D-tetra-O-acetylcyclohexane-1,2,4/3-tetrol 
• 175774-37-5 (1R,2S,6R,7S)-8,9-Dioxa-3,4-diaza-tricyclo[5.2.2.0^2,6]undec-3-ene 
• 175774-37-5 (1S,2S,6R,7R)-8,9-Dioxa-3,4-diaza-tricyclo[5.2.2.0^2,6]undec-3-ene 
• 1264750-38-0 (1RS,2RS,3SR,4SR)-3,6-dibromocyclohexane-1,2-diol 

Relevant academic research and scientific papers

Singlet oxygen generation from poly[4-diacetoxyiodo]styrene and hydrogen peroxide

Treatment of hydrogen peroxide with a polymer-supported hypervalent iodine compound, poly[4-diacetoxyiodo] styrene (PDAIS), generates singlet molecular oxygen (1O2). Singlet oxygen generation was proved by trapping with typical organic compounds such as conjugated dienes, aromatic dienes, and electron-rich alkene. When compared to monomer analogue, the use of PDAIS in peroxidation of substrates gave slightly better yields (45%–96%). Regeneration and reuse of PDAIS showed similar activity. The mechanism underlying generation of singlet oxygen and reaction scope was examined.

Ring-opening metathesis polymer sphere-supported seco-porphyrazines: Efficient and recyclable photooxygenation catalysts

Crossover Linstead macrocyclization of norbornenyl-tagged diaminomaleonitrile with dipropylmaleonitrile gave the corresponding magnesium diaminohexapropylporphyrazine, which was subsequently converted into its zinc seco-derivative. Polymerization gave the corresponding ROMPgel and ROMPsphere (ROMP = ring-opening metathesis polymer) reagents, the latter of which proved efficient as an immobilized catalyst for the sensitized production of singlet oxygen for the purification-minimized parallel synthesis of endoperoxides and ene adducts.

Synthesis and Antimalarial Activity of Trioxaquine Derivatives

Trioxaquines are dual molecules that contain a trioxane motif linked to an aminoquinoline entity. Among the different compounds of this series, trioxaquine cis-15 (DU1302c), prepared from α-terpinene, a cheap natural product, showed efficient antimalarial activity in vitro on both sensitive and resistant strains of Plasmodium falciparum (IC50 = 5-19 nM). A stereochemical description of this stable, nontoxic, and non-genotoxic antimalarial agent is detailed. Mice infected with P. vinckei were successfully treated with cis-15 in a four-day suppressive test. The doses required to decrease parasitemia by 50% (ED50) were 5 and 18 mg kg -1d-1 after intraperitoneal and oral administration, respectively. Parasitemia clearance was complete without recrudescence at an intraperitoneal dose of 20 mgkg-1d-1.