6671-70-1

Basic information

• Product Name: 2,3-dioxabicyclo[2.2.2]oct-5-ene
• Synonyms: 2,3-Dioxabicyclo(2.2.2)oct-5-ene; 2,3-Dioxabicyclo[2.2.2]oct-5-ene; 2,3-Dioxabicyclo[2.2.2]oct-7-ene
• CAS NO: 6671-70-1
• Molecular Formula: C₆H₈O₂
• Molecular Weight: 112.1265
• Mol File: 6671-70-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 115.3°C at 760 mmHg
• Flash Point: 56.8°C
• Density: 1.14g/cm³
• Vapor Pressure: 22.7mmHg at 25°C
• Refractive Index: 1.492
• CAS DataBase Reference: 2,3-dioxabicyclo[2.2.2]oct-5-ene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dioxabicyclo[2.2.2]oct-5-ene(6671-70-1)
• EPA Substance Registry System: 2,3-dioxabicyclo[2.2.2]oct-5-ene(6671-70-1)

Safety Data

• Hazardous Substances Data: 6671-70-1(Hazardous Substances Data)

Upstream product

• 1165952-91-9 cyclohexa-1,3-diene 

Downstream Products

• 53762-85-9 (1S,4R)-Cyclohex-2-ene-1,4-diol 
• 175774-37-5 (1R,2S,6R,7S)-8,9-Dioxa-3,4-diaza-tricyclo[5.2.2.0^2,6]undec-3-ene 
• 175774-37-5 (1S,2S,6R,7R)-8,9-Dioxa-3,4-diaza-tricyclo[5.2.2.0^2,6]undec-3-ene 
• 78776-45-1 cis-2-cyclohexenyl-1,4-diacetate 
• 1319205-46-3 3,6-difluorocyclohexane-1,2-diol 
• 1319205-50-9 all-syn-1,2,3,4-tetrafluorocyclohexane 
• 1264750-38-0 (1RS,2RS,3SR,4SR)-3,6-dibromocyclohexane-1,2-diol 
• 20021-56-1 (+/-)-1D-tetra-O-acetylcyclohexane-1,2,4/3-tetrol 
• 2975-92-0 (+/-)-1D-cyclohexane-1,2,4/3-tetrol 

Relevant articles and documents

Singlet oxygen generation from poly[4-diacetoxyiodo]styrene and hydrogen peroxide

Treatment of hydrogen peroxide with a polymer-supported hypervalent iodine compound, poly[4-diacetoxyiodo] styrene (PDAIS), generates singlet molecular oxygen (1O2). Singlet oxygen generation was proved by trapping with typical organic compounds such as conjugated dienes, aromatic dienes, and electron-rich alkene. When compared to monomer analogue, the use of PDAIS in peroxidation of substrates gave slightly better yields (45%–96%). Regeneration and reuse of PDAIS showed similar activity. The mechanism underlying generation of singlet oxygen and reaction scope was examined.

Synthesis and Antimalarial Activity of Trioxaquine Derivatives

Trioxaquines are dual molecules that contain a trioxane motif linked to an aminoquinoline entity. Among the different compounds of this series, trioxaquine cis-15 (DU1302c), prepared from α-terpinene, a cheap natural product, showed efficient antimalarial activity in vitro on both sensitive and resistant strains of Plasmodium falciparum (IC50 = 5-19 nM). A stereochemical description of this stable, nontoxic, and non-genotoxic antimalarial agent is detailed. Mice infected with P. vinckei were successfully treated with cis-15 in a four-day suppressive test. The doses required to decrease parasitemia by 50% (ED50) were 5 and 18 mg kg -1d-1 after intraperitoneal and oral administration, respectively. Parasitemia clearance was complete without recrudescence at an intraperitoneal dose of 20 mgkg-1d-1.