2-(5-(4-fluorophenyl)-4-(2-(3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepin-4-yl)ethyl)-1-isopropyl-1H-pyrazol-3-yl)ethanamine

Base Information

Chemical Name:2-(5-(4-fluorophenyl)-4-(2-(3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepin-4-yl)ethyl)-1-isopropyl-1H-pyrazol-3-yl)ethanamine
CAS No.:1311165-08-8
Molecular Formula:C₃₂H₄₀F₂N₆
Molecular Weight:546.707
Hs Code.:

2-(5-(4-fluorophenyl)-4-(2-(3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepin-4-yl)ethyl)-1-isopropyl-1H-pyrazol-3-yl)ethanamine

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Chemical Property of 2-(5-(4-fluorophenyl)-4-(2-(3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepin-4-yl)ethyl)-1-isopropyl-1H-pyrazol-3-yl)ethanamine

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Technology Process of 2-(5-(4-fluorophenyl)-4-(2-(3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepin-4-yl)ethyl)-1-isopropyl-1H-pyrazol-3-yl)ethanamine

There total 3 articles about 2-(5-(4-fluorophenyl)-4-(2-(3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepin-4-yl)ethyl)-1-isopropyl-1H-pyrazol-3-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956316-86-2
benzyl 2-(4-((1,3-dioxolan-2-yl)methyl)-5-(4-fluorophenyl)-1-isopropyl-1H-pyrazol-3-yl)ethylcarbamate

: 851375-22-9
3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine

: 1311165-08-8
2-(5-(4-fluorophenyl)-4-(2-(3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepin-4-yl)ethyl)-1-isopropyl-1H-pyrazol-3-yl)ethanamine

Guidance literature:: With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; In tert-Amyl alcohol; at 45 ℃; for 18h; under 2068.65 Torr;
DOI:10.1021/op2001194

Reference yield:

: 956316-85-1
benzyl 3-(2-isopropylhydrazono)propylcarbamate

: 851375-22-9
3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine

: 1311165-08-8
2-(5-(4-fluorophenyl)-4-(2-(3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepin-4-yl)ethyl)-1-isopropyl-1H-pyrazol-3-yl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 20 °C

2: hydrogenchloride; palladium 10% on activated carbon; water; hydrogen / tert-Amyl alcohol / 18 h / 45 °C / 2068.65 Torr

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; triethylamine; In tert-Amyl alcohol;
DOI:10.1021/op2001194

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 851375-22-9
3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine

: 1311165-08-8
2-(5-(4-fluorophenyl)-4-(2-(3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepin-4-yl)ethyl)-1-isopropyl-1H-pyrazol-3-yl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / toluene / 18 h / Reflux; Inert atmosphere

2: triethylamine / 20 °C

3: hydrogenchloride; palladium 10% on activated carbon; water; hydrogen / tert-Amyl alcohol / 18 h / 45 °C / 2068.65 Torr

With piperidine; hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; triethylamine; In tert-Amyl alcohol; toluene; 1: Henry reaction;
DOI:10.1021/op2001194