Naphthalene, 2-methoxy-1-methyl-

Base Information

• Chemical Name: Naphthalene, 2-methoxy-1-methyl-
• CAS No.: 1130-80-9
• Molecular Formula: C12H12O
• Molecular Weight: 172.227
• Hs Code.: 2909309090
• Mol file: 1130-80-9.mol

Synonyms:1-methyl-2-benzimidazolecarboxylic acid methyl ester;2-methoxy-1-methyl-benzimidazole;2-Methoxy-1-methyl-naphthalin;1-methyl-1H-benzoimidazole-2-carboxylic acid methyl ester;Naphthalene, 2-methoxy-1-methyl-;1-Methyl-2-methoxynaphthalene;methyl 1-methyl-2-benzimidazolecarboxylate;2-methoxy-1-methyl-naphthalene;1-Methyl-2-naphthyl-methylether;

Chemical Property of Naphthalene, 2-methoxy-1-methyl-

Chemical Property:

• PSA: 9.23000
• LogP: 3.15680

Purity/Quality:

98%min ^*data from raw suppliers

2-METHOXY-1-METHYLNAPHTHALENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Naphthalene, 2-methoxy-1-methyl-

There total 34 articles about Naphthalene, 2-methoxy-1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-bromo-2-methoxynaphthalene (3401-47-6) + dilithium tetramethylzincate → 2-methoxy-1-methylnaphthalene (1130-80-9)

Guidance literature:

1-bromo-2-methoxynaphthalene; dilithium tetramethylzincate; In tetrahydrofuran; at 0 ℃; for 2h;

With oxovanadium(V) ethoxydichloride; at 20 ℃; for 5h; Further stages.;

DOI:10.1021/jo000976u

Reference yield: 96.0%

6-Bromo-1-(chloromethyl)-2-methoxynaphthalene (92643-16-8) → 2-methoxy-1-methylnaphthalene (1130-80-9)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In ethyl acetate; for 2h; under 2585.7 Torr;

DOI:10.1021/jo00199a048

Reference yield: 96.0%

1-bromo-2-methoxynaphthalene (3401-47-6) + lithium methyltriolborate → 2-methoxy-1-methylnaphthalene (1130-80-9)

Guidance literature:

With palladium diacetate; ruphos; In methanol; water; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.3390/molecules18010430

upstream raw materials:

Hippuric Acid

2-methoxy-1-naphthaldehyde

4-(2-methoxy-5,6-benzobenzylidene)-2-phenyl-5-oxazolone

1-methyl-2-naphthol

Downstream raw materials:

1-Methylnaphthalene

2-acetyl-cis-cinnamic acid methyl ester

1,6-Dimethyl-[2]naphthol

2-(6-hydroxy-5-methyl-[2]naphthylmethyl)-benzoic acid

Refernces

• 1、 McCarthy, James R.,Huffman, John C.. "Chloromethylation of 1-Bromo-2-methoxynaphthalene. A Revised Structure for the Product". . p. 4995 - 4997. Retrieved 1984.
• 2、 Kalvet, Indrek,Sperger, Theresa,Scattolin, Thomas,Magnin, Guillaume,Schoenebeck, Franziska. "Palladium(I) Dimer Enabled Extremely Rapid and Chemoselective Alkylation of Aryl Bromides over Triflates and Chlorides in Air". supporting information. p. 7078 - 7082. Retrieved 2017/06/13.
• 3、 Liu, Xiangqian,Hsiao, Chien-Chi,Kalvet, Indrek,Leiendecker, Matthias,Guo, Lin,Schoenebeck, Franziska,Rueping, Magnus. "Lewis Acid Assisted Nickel-Catalyzed Cross-Coupling of Aryl Methyl Ethers by C-O Bond-Cleaving Alkylation: Prevention of Undesired β-Hydride Elimination". . p. 6093 - 6098. Retrieved 2016/05/19.