6-BROMO-1-(CHLOROMETHYL)-2-METHOXYNAPHTHALENE

Base Information

• Chemical Name: 6-BROMO-1-(CHLOROMETHYL)-2-METHOXYNAPHTHALENE
• CAS No.: 92643-16-8
• Molecular Formula: C12H10 Br Cl O
• Molecular Weight: 285.568
• Hs Code.: 2922210060
• Mol file: 92643-16-8.mol

Synonyms:6-Bromo-1-(chloromethyl)-2-methoxynaphthalene

Chemical Property of 6-BROMO-1-(CHLOROMETHYL)-2-METHOXYNAPHTHALENE

Chemical Property:

• Vapor Pressure: 1.27E-05mmHg at 25°C
• Melting Point: 144 °C
• Refractive Index: 1.631
• Boiling Point: 379.5°Cat760mmHg
• Flash Point: 183.3°C
• PSA: 9.23000
• Density: 1.491g/cm³
• LogP: 4.34970

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-1-chloromethyl-2-methoxynaphthalene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-1-(CHLOROMETHYL)-2-METHOXYNAPHTHALENE

There total 2 articles about 6-BROMO-1-(CHLOROMETHYL)-2-METHOXYNAPHTHALENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.5%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-bromo-2-methoxynaphthalene (3401-47-6) → 6-Bromo-1-(chloromethyl)-2-methoxynaphthalene (92643-16-8)

Guidance literature:

With hydrogenchloride; In water; acetic acid; 1) 45 deg C, 2) 60 deg C;

DOI:10.1021/jo00199a048

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Bromo-6-methoxynaphthalene (5111-65-9) → 6-Bromo-1-(chloromethyl)-2-methoxynaphthalene (92643-16-8)

Guidance literature:

With hydrogenchloride; acetic acid; Durchleiten von HCl;

DOI:10.1039/jr9480000261

Reference yield: 87.0%

(S)-tert-butyl 1-(4-nitrobenzoyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylcarbamate + 6-Bromo-1-(chloromethyl)-2-methoxynaphthalene (92643-16-8) → (S)-tertbutyl 1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-5-(4-nitrobenzoyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylcarbamate

Guidance literature:

With sodium hydride; caesium carbonate; In N,N-dimethyl-formamide; for 16h;

upstream raw materials:

formaldehyd

2-Bromo-6-methoxynaphthalene

1-bromo-2-methoxynaphthalene

Downstream raw materials:

6-Bromo-2-methoxy-1-naphthaleneacetonitrile

2-methoxy-1-methylnaphthalene