2,6-dichloro-N-(pyridin-4-yl)benzamide

Base Information

• Chemical Name: 2,6-dichloro-N-(pyridin-4-yl)benzamide
• CAS No.: 113204-35-6
• Molecular Formula: C12H8Cl2N2O
• Molecular Weight: 267.114
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID401015650
• ChEMBL ID: CHEMBL1327969
• Mol file: 113204-35-6.mol

Synonyms:2,6-dichloro-N-(pyridin-4-yl)benzamide;113204-35-6;Benzamide, 2,6-dichloro-N-4-pyridinyl-;2,6-dichloro-N-pyridin-4-ylbenzamide;2,6-Dichloro-N-4-pyridinyl-benzamide;CHEMBL1327969;2,6-Dichloro-N-(4-pyridyl)benzamide;2,6-Dichloro-N-pyridin-4-yl-benzamide;Oprea1_062296;Oprea1_381975;MLS001211622;DTXSID401015650;HMS2836N03;BDBM50439025;CS1149;MFCD01195760;STK098832;AKOS000678330;AS-46494;SMR000515591;2,6-dichloro-N~1~-(4-pyridyl)benzamide;CS-0315280;FT-0755836;A894462;SR-01000370136;SR-01000370136-1

Chemical Property of 2,6-dichloro-N-(pyridin-4-yl)benzamide

Chemical Property:

• PSA: 41.99000
• LogP: 3.71370
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 266.0013683
• Heavy Atom Count: 17
• Complexity: 259

Purity/Quality:

98%min ^*data from raw suppliers

2,6-Dichloro-N-(pyridin-4-yl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)Cl)C(=O)NC2=CC=NC=C2)Cl

Technology Process of 2,6-dichloro-N-(pyridin-4-yl)benzamide

There total 1 articles about 2,6-dichloro-N-(pyridin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-aminopyridine (504-24-5) + 2,6-Dichlorobenzoyl chloride (4659-45-4) → 2,6-dichloro-N-(pyridin-4-yl)benzamide (113204-35-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 23 ℃; for 4h;

DOI:10.1016/j.ejmech.2013.03.070

Reference yield: 67.0%

2,6-dichloro-N-(pyridin-4-yl)benzamide (113204-35-6) + methyl iodide (74-88-4) → 2,6-dichloro-N-methyl-N-(pyridin-4-yl)benzamide (1454838-71-1)

Guidance literature:

2,6-dichloro-N-(pyridin-4-yl)benzamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 0 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.03.070

Reference yield: 44.0%

2,6-dichloro-N-(pyridin-4-yl)benzamide (113204-35-6) → N-(2,6-dichlorobenzyl)pyridin-4-amine (1454838-70-0)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; Reflux; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.03.070

upstream raw materials:

4-aminopyridine

2,6-Dichlorobenzoyl chloride

Downstream raw materials:

N-(2,6-dichlorobenzyl)pyridin-4-amine

2,6-dichloro-N-methyl-N-(pyridin-4-yl)benzamide

Refernces