Trifluoro-acetic acid (3R,5S)-5-[2-bromo-4-methoxy-5-(toluene-4-sulfonyloxy)-phenylcarbamoyl]-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl ester

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Chemical Name:Trifluoro-acetic acid (3R,5S)-5-[2-bromo-4-methoxy-5-(toluene-4-sulfonyloxy)-phenylcarbamoyl]-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl ester
CAS No.:105842-35-1
Molecular Formula:C₂₃H₁₉BrF₆N₂O₈S
Molecular Weight:677.373
Hs Code.:

Trifluoro-acetic acid (3R,5S)-5-[2-bromo-4-methoxy-5-(toluene-4-sulfonyloxy)-phenylcarbamoyl]-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl ester

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Chemical Property of Trifluoro-acetic acid (3R,5S)-5-[2-bromo-4-methoxy-5-(toluene-4-sulfonyloxy)-phenylcarbamoyl]-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl ester

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Technology Process of Trifluoro-acetic acid (3R,5S)-5-[2-bromo-4-methoxy-5-(toluene-4-sulfonyloxy)-phenylcarbamoyl]-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl ester

There total 1 articles about Trifluoro-acetic acid (3R,5S)-5-[2-bromo-4-methoxy-5-(toluene-4-sulfonyloxy)-phenylcarbamoyl]-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89625-38-7
2-bromo-4-methoxy-5-tosyloxyaniline

: 83577-94-0
(3R,5S)-5-chlorocarbonyl-1-(trifluoroacetyl)pyrrolidin-3-yl trifluoroacetate

: 105842-35-1
Trifluoro-acetic acid (3R,5S)-5-[2-bromo-4-methoxy-5-(toluene-4-sulfonyloxy)-phenylcarbamoyl]-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl ester

Guidance literature:: DOI:10.3987/R-1986-05-1257

Reference yield:

: 105842-35-1
Trifluoro-acetic acid (3R,5S)-5-[2-bromo-4-methoxy-5-(toluene-4-sulfonyloxy)-phenylcarbamoyl]-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl ester

: 105823-11-8
Toluene-4-sulfonic acid (2R,11aS)-2-hydroxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaHCO₃

2: di-isopropylethylamine

3: NH₃ / methanol

4: 69 percent / n-Bu₃N / Pd(PPh₃)4 / toluene / 24 h / 110 °C / 7600 Torr

5: 27 percent / aq. HCl / methanol

With hydrogenchloride; tributyl-amine; ammonia; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; toluene;
DOI:10.1039/c39860000841

Reference yield:

: 105842-35-1
Trifluoro-acetic acid (3R,5S)-5-[2-bromo-4-methoxy-5-(toluene-4-sulfonyloxy)-phenylcarbamoyl]-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl ester

: 105823-10-7
(2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaHCO₃

2: di-isopropylethylamine

3: NH₃ / methanol

4: 69 percent / n-Bu₃N / Pd(PPh₃)4 / toluene / 24 h / 110 °C / 7600 Torr

5: 68 percent / aq. HCl / methanol

With hydrogenchloride; tributyl-amine; ammonia; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; toluene;
DOI:10.1039/c39860000841