Desfluoro Flupirtine Hydrochloride

Base Information

• Chemical Name: Desfluoro Flupirtine Hydrochloride
• CAS No.: 21630-56-8
• Molecular Formula: C₁₅H₁₈N₄O₂*ClH
• Molecular Weight: 322.794
• Mol file: 21630-56-8.mol

Synonyms:

Chemical Property of Desfluoro Flupirtine Hydrochloride

Chemical Property:

Purity/Quality:

Desfluoro Flupirtine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Desfluoro Flupirtine is an impurity in the synthesis of Flupirtine (F598510), an analgesic. Substituted pyridine with central analgesic properties.

Technology Process of Desfluoro Flupirtine Hydrochloride

There total 7 articles about Desfluoro Flupirtine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) → ethyl <2-amino-6-(benzylamino)pyridin-3-yl>carbamate hydrochloride (21630-56-8)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonia

2: triethylamine / dioxane

3: H₂ / Raney nickel / dioxane / 50 °C / 3750.3 Torr

4: dioxane / 1 h

With ammonia; hydrogen; triethylamine; nickel; In 1,4-dioxane;

DOI:10.1021/jm00045a005

Reference yield:

2-amino-6-chloro-3-nitropyridine (27048-04-0) → ethyl <2-amino-6-(benzylamino)pyridin-3-yl>carbamate hydrochloride (21630-56-8)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dioxane

2: H₂ / Raney nickel / dioxane / 50 °C / 3750.3 Torr

3: dioxane / 1 h

With hydrogen; triethylamine; nickel; In 1,4-dioxane;

DOI:10.1021/jm00045a005

Reference yield:

N6-benzyl-3-nitro-pyridine-2,6-diamine (21626-43-7) → ethyl <2-amino-6-(benzylamino)pyridin-3-yl>carbamate hydrochloride (21630-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney nickel / dioxane / 50 °C / 3750.3 Torr

2: dioxane / 1 h

With hydrogen; nickel; In 1,4-dioxane;

DOI:10.1021/jm00045a005

upstream raw materials:

chloroformic acid ethyl ester

N⁶-benzyl-pyridine-2,3,6-triaine

2,3-Diaminopyridine

spiropyridine>

Refernces

• 1、 Schwoch,Kramer,Neidlein,Suschitzky. "2,3-Dihydrospiro[1H-4- and 5-azabenzimidazole-2,1'-cyclohexane] (= spiro[cyclohexane-1,2'(3'H)-1'H-imidazo[4,5-b]pyridine] and spiro[cyclohexane-1,2'(3'H)-1'H-imidazo[4,5-c]pyridine]): Reactions with nucleophiles". . p. 2175 - 2190. Retrieved 2007/10/02.