C₂₁H₂₄N₆O₈

Base Information

Chemical Name:C₂₁H₂₄N₆O₈
CAS No.:2267306-15-8
Molecular Formula:C₂₁H₂₄N₆O₈
Molecular Weight:488.457
Hs Code.:

C<sub>21</sub>H<sub>24</sub>N<sub>6</sub>O<sub>8</sub>

Synonyms:

Suppliers and Price of C₂₁H₂₄N₆O₈

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Pomalidomide-PEG3-azide
50 mg
$ 440.00

Iris Biotech GmbH
Pomalidomid-PEG3-N3
50 mg
$ 607.50

Total 4 raw suppliers

Chemical Property of C₂₁H₂₄N₆O₈

Chemical Property:

Melting Point:165 °C

Purity/Quality:

97% ^*data from raw suppliers

Pomalidomide-PEG3-azide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Protein degrader builiding block Pomalidomide-PEG3-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Technology Process of C₂₁H₂₄N₆O₈

There total 13 articles about C₂₁H₂₄N₆O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.5%

: 2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxoethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate

: 2267306-15-8
C₂₁H₂₄N₆O₈

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 5h;
DOI:10.1016/j.bioorg.2022.105605

Reference yield: 62.0%

: 19171-19-8,202271-89-4
pomalidomide

: 172531-36-1
tert-butyl 2-[2-(2-(2-azidoethoxy)ethoxy)ethoxy]acetate

: 2267306-15-8
C₂₁H₂₄N₆O₈

Guidance literature:: tert-butyl 2-[2-(2-(2-azidoethoxy)ethoxy)ethoxy]acetate; With water; sodium hydroxide; In methanol;

With oxalyl dichloride; In methanol; for 0.5h;

pomalidomide; In methanol; dichloromethane; N,N-dimethyl-formamide; at 90 ℃; for 0.333333h;