[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[(prop-1-en-2-yl)phenyl]-propyl]sulfonyl]methyl]cyclopropane acetic acid

Base Information

• Chemical Name: [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[(prop-1-en-2-yl)phenyl]-propyl]sulfonyl]methyl]cyclopropane acetic acid
• CAS No.: 1351973-23-3
• Molecular Formula: C₃₅H₃₄ClNO₄S
• Molecular Weight: 600.178
• Mol file: 1351973-23-3.mol

Synonyms:

Chemical Property of [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[(prop-1-en-2-yl)phenyl]-propyl]sulfonyl]methyl]cyclopropane acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[(prop-1-en-2-yl)phenyl]-propyl]sulfonyl]methyl]cyclopropane acetic acid

There total 8 articles about [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[(prop-1-en-2-yl)phenyl]-propyl]sulfonyl]methyl]cyclopropane acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.2%

[1-[(R)-1-(3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]-phenyl)-3-(2-isopropenylphenyl)propylsulfanylmethyl]cyclopropyl]acetic acid dicyclohexylamine salt (1197374-12-1) → [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]-phenyl]-3-[(prop-1-en-2-yl)phenyl]propyl]sulfinyl]methyl]-cyclopropaneacetic acid (1250477-73-6) + [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[(prop-1-en-2-yl)phenyl]-propyl]sulfonyl]methyl]cyclopropane acetic acid (1351973-23-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 25 - 30 ℃; for 2h;

Reference yield:

C29H26ClNO (1197414-05-3) → [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[(prop-1-en-2-yl)phenyl]-propyl]sulfonyl]methyl]cyclopropane acetic acid (1351973-23-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride / water; ethyl acetate / 25 - 30 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 30 °C

2.2: 1 h / 0 - 5 °C

3.1: sodium methylate / methanol; N,N-dimethyl-formamide / 0 - 5 °C

4.1: ethyl acetate / 25 - 30 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 25 - 30 °C

With hydrogenchloride; sodium methylate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propan-1-ol hydrochloride (1197374-10-9) → [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[(prop-1-en-2-yl)phenyl]-propyl]sulfonyl]methyl]cyclopropane acetic acid (1351973-23-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 30 °C

1.2: 1 h / 0 - 5 °C

2.1: sodium methylate / methanol; N,N-dimethyl-formamide / 0 - 5 °C

3.1: ethyl acetate / 25 - 30 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 25 - 30 °C

With sodium methylate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

[1-[(R)-1-(3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]-phenyl)-3-(2-isopropenylphenyl)propylsulfanylmethyl]cyclopropyl]acetic acid dicyclohexylamine salt

[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-[1-(1-methyl)ethenyl]phenyl]propyl]thio]methyl]cyclopropaneacetic acid

(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propan-1-ol hydrochloride

(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl acetate

Downstream raw materials:

[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(hydroxy-1-methylethyl)phenyl]propyl]-sulfonyl]methyl]-cyclopropane acetic acid

Refernces