Phenol, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-2-fluoro-

Base Information

Chemical Name:Phenol, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-2-fluoro-
CAS No.:113984-79-5
Molecular Formula:C19H35FO3Si2
Molecular Weight:386.655
Hs Code.:
Mol file:113984-79-5.mol

Synonyms:

Suppliers and Price of Phenol, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-2-fluoro-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phenol, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-2-fluoro-

Chemical Property:

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Technology Process of Phenol, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-2-fluoro-

There total 7 articles about Phenol, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[[(1,1-dimethylethyl)dimethylsil yl]oxy]methyl]-2-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 113984-79-5
3-(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluoro-5-hydroxybenzene

Guidance literature:

Reference yield: 64.0%

: 121-43-7,63156-11-6
Trimethyl borate

: 113984-79-5
3-(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluoro-5-hydroxybenzene

Guidance literature:: 2-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-1-fluoro-benzene; With sec.-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

Trimethyl borate; In tetrahydrofuran; hexane; for 0.5h;

With water; dihydrogen peroxide; acetic acid; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 4.5h;

Reference yield:

: 113984-76-2
1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene

: 113984-79-5
3-(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluoro-5-hydroxybenzene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sec-BuLi, 2.) B(OMe)3, 3.) H₂O₂ / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 3.) HOAc, 25 deg C, 24 h

2: 100 percent / imidazole / dimethylformamide / 15 h / 25 °C

3: 1.) sec-BuLi, 2.) B(OMe)3, 3.) H₂O₂ / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 3.) HOAc, 25 deg C, 24 h

With 1H-imidazole; Trimethyl borate; dihydrogen peroxide; sec.-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)95560-6