3,5-bis(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene

Base Information

Chemical Name:3,5-bis(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene
CAS No.:113984-81-9
Molecular Formula:C₂₅H₄₉FO₃Si₃
Molecular Weight:500.917
Hs Code.:

Synonyms:3,5-bis(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-bis(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene

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Technology Process of 3,5-bis(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene

There total 6 articles about 3,5-bis(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 113984-79-5
3-(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluoro-5-hydroxybenzene

: 18162-48-6
tert-butyldimethylsilyl chloride

: 113984-81-9
3,5-bis(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 15h;
DOI:10.1016/S0040-4039(00)95560-6

Reference yield:

: 113984-76-2
1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene

: 113984-81-9
3,5-bis(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sec-BuLi, 2.) B(OMe)3, 3.) H₂O₂ / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 3.) HOAc, 25 deg C, 24 h

2: 100 percent / imidazole / dimethylformamide / 15 h / 25 °C

3: 1.) sec-BuLi, 2.) B(OMe)3, 3.) H₂O₂ / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 3.) HOAc, 25 deg C, 24 h

4: 100 percent / imidazole / dimethylformamide / 15 h / 25 °C

With 1H-imidazole; Trimethyl borate; dihydrogen peroxide; sec.-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)95560-6

Reference yield:

: 113984-77-3
1-(tert-butyldimethylsiloxymethyl)-4-fluoro-3-hydroxybenzene

: 113984-81-9
3,5-bis(tert-butyldimethylsilyloxy)-1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / imidazole / dimethylformamide / 15 h / 25 °C

2: 1.) sec-BuLi, 2.) B(OMe)3, 3.) H₂O₂ / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 3.) HOAc, 25 deg C, 24 h

3: 100 percent / imidazole / dimethylformamide / 15 h / 25 °C

With 1H-imidazole; Trimethyl borate; dihydrogen peroxide; sec.-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)95560-6