Technology Process of (R,S)-[(3,6-diphenyl-2,5-dihydro-2(H)-1,2,4-triazin-5-yl)]cymantrene
There total 1 articles about (R,S)-[(3,6-diphenyl-2,5-dihydro-2(H)-1,2,4-triazin-5-yl)]cymantrene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
H2O;
In
tetrahydrofuran; hexane;
under Ar; soln. of n-BuLi in hexane added to soln. of cymantrene in anhyd. THF at -78°C; stirred for 30 min; soln. of N3C3HPh2 in anhyd. THF added; stirred at -78°C for 1.5 h and at room temp. for 1 h; purified by chromy. (silica gel, benzene); concd. to dryness in vac.; elem. anal.;
DOI:10.1021/om200159f
- Guidance literature:
-
With
DDQ;
In
tetrahydrofuran;
under Ar; soln. of DDQ in THF added to soln. of Mn complex in anhyd. THFat room temp.; filtered through neutral alumina layer; alumina layer washed with THF; solvent evapd.; purified by chromy. (silica gel, benzene-EtOAc 9.5:0.5); concd. to dryness in vac.; elem. anal.;
DOI:10.1021/om200159f
- Guidance literature:
-
With
NaH;
In
tetrahydrofuran;
under Ar; NaH added to soln. of Mn complex in dry THF at room temp.; stirred until complete dissolution; EtI added; stirred at room temp. for 5 h; concd. in vac.; purified by chromy. (silica gel, benzene-EtOAc 9:1); elem. anal.;
DOI:10.1021/om200159f
