4-Chloro-6-(4-morpholinyl)-1,3,5-triazin-2-ylamine

Base Information

• Chemical Name: 4-Chloro-6-(4-morpholinyl)-1,3,5-triazin-2-ylamine
• CAS No.: 114209-49-3
• Molecular Formula: C7H10ClN5O
• Molecular Weight: 215.642
• European Community (EC) Number: 853-789-6
• Mol file: 114209-49-3.mol

Synonyms:4-CHLORO-6-(4-MORPHOLINYL)-1,3,5-TRIAZIN-2-YLAMINE;114209-49-3;4-chloro-6-morpholin-4-yl-1,3,5-triazin-2-amine;4-chloro-6-(morpholin-4-yl)-1,3,5-triazin-2-amine;4-Chloro-6-morpholino-1,3,5-triazin-2-amine;SCHEMBL18383753;AKOS012159458;CS-0247091;EN300-3564815

Chemical Property of 4-Chloro-6-(4-morpholinyl)-1,3,5-triazin-2-ylamine

Chemical Property:

• PSA: 77.16000
• LogP: 0.59000
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 215.0573877
• Heavy Atom Count: 14
• Complexity: 189

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-6-(4-morpholinyl)-1,3,5-triazin-2-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1COCCN1C2=NC(=NC(=N2)N)Cl

Technology Process of 4-Chloro-6-(4-morpholinyl)-1,3,5-triazin-2-ylamine

There total 2 articles about 4-Chloro-6-(4-morpholinyl)-1,3,5-triazin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + 4,6-dichloro-1,3,5-triazin-2-amine (933-20-0) → 4-chloro-6-(morpholin-4-yl)-1,3,5-triazin-2-amine (114209-49-3)

Guidance literature:

With water;

DOI:10.1021/ja01191a053

Reference yield:

morpholine (110-91-8,99108-56-2) + 1,3,5-trichloro-2,4,6-triazine (108-77-0) → 4-chloro-6-(morpholin-4-yl)-1,3,5-triazin-2-amine (114209-49-3)

Guidance literature:

1,3,5-trichloro-2,4,6-triazine; With ammonium hydroxide; In water; at 0 - 10 ℃; for 2h;

morpholine; With sodium dodecyl-sulfate; at 45 - 50 ℃; for 2h;

Reference yield: 65.0%

4-chloro-6-(morpholin-4-yl)-1,3,5-triazin-2-amine (114209-49-3) + 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (214360-76-6) → 3-(4-amino-6-morpholino-1,3,5-triazin-2-yl)phenol (1391925-06-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/acsmedchemlett.5b00322

upstream raw materials:

morpholine

4,6-dichloro-1,3,5-triazin-2-amine

1,3,5-trichloro-2,4,6-triazine

Downstream raw materials:

3-(4-amino-6-morpholino-1,3,5-triazin-2-yl)phenol