2-Amino-4,6-dichloro-S-triazine

Base Information

• Chemical Name: 2-Amino-4,6-dichloro-S-triazine
• CAS No.: 933-20-0
• Molecular Formula: C3H2Cl2N4
• Molecular Weight: 164.982
• Hs Code.: 2933699090
• European Community (EC) Number: 625-682-2
• NSC Number: 267458,71988
• UNII: T5S5IYO89G
• DSSTox Substance ID: DTXSID40239372
• Nikkaji Number: J32.979G
• Wikidata: Q27289706
• Mol file: 933-20-0.mol

Synonyms:933-20-0;2-Amino-4,6-dichlorotriazine;4,6-dichloro-1,3,5-triazin-2-amine;2-AMINO-4,6-DICHLORO-S-TRIAZINE;2-Amino-4,6-dichloro-1,3,5-triazine;1,3,5-Triazin-2-amine, 4,6-dichloro-;4,6-Dichloro-1,3,5-trazin-2-amine;s-Triazine, 2-amino-4,6-dichloro-;dichloro-1,3,5-triazin-2-amine;C3H2Cl2N4;NSC 71988;MFCD00078331;UNII-T5S5IYO89G;NSC 267458;BRN 0124266;T5S5IYO89G;AI3-51037;2,4-dichloro-6-amino-s-triazine;NSC71988;NSC-71988;NSC-267458;2,4-Dichloro-6-amino-1,3,5-triazine;s-Triazine,6-dichloro-;4,6-dichloro-[1,3,5]triazin-2-ylamine;5-26-08-00011 (Beilstein Handbook Reference);1,5-Triazin-2-amine, 4,6-dichloro-;SCHEMBL79810;1189493-13-7;S-DICHLOROAMINOTRIAZINE;AMINODICHLORO-S-TRIAZINE;C3-H2-Cl2-N4;DTXSID40239372;2-Amino-4,6-dichloro-s-triazin;4,6-dichloro-2-amino-s-triazine;BCP00519;s-Triazine,2-amino-4,6-dichloro-;NSC267458;STK505600;AKOS005145931;CS-W008081;SB40030;4,6-DICHLORO-S-TRIAZIN-2-AMINE;2,6-DICHLORO-4-AMINO-S-TRIAZINE;2-amino-4,6-dichloro-[1,3,5]triazine;DS-11600;6-Amino-2,4-dichloro-[1,3,5]triazine;LS-155042;4,6-dichloro-1,2,3-triazin-2(1H)-amine;4,6-Dichloro-1,3,5-triazin-2-ylamine #;AM20120343;BB 0241900;FT-0600528;EN300-247097;2-Amino-4,6-dichloro-1,3,5-triazine, >=96%;J-514114;Q27289706

Chemical Property of 2-Amino-4,6-dichloro-S-triazine

Chemical Property:

• Vapor Pressure: 0.043mmHg at 25°C
• Melting Point: 239-242 °C
• Refractive Index: 1.73
• Boiling Point: 428.8 °C at 760 mmHg
• PKA: 2.28±0.10(Predicted)
• Flash Point: 213.1 °C
• PSA: 64.69000
• Density: 1.731 g/cm³
• LogP: 1.34180
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO, Methanol (Sparingly)
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 163.9656515
• Heavy Atom Count: 9
• Complexity: 89.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-4,6-dichloro-s-triazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 23-36/37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1(=NC(=NC(=N1)Cl)Cl)N
• Uses: An aromatic intermediate compound, 2-Amino-4,6-dichlorotriazine can be useful for the preparation of substituted melamine, ammelides, and ammelines.

Technology Process of 2-Amino-4,6-dichloro-S-triazine

There total 6 articles about 2-Amino-4,6-dichloro-S-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,3,5-trichloro-2,4,6-triazine (108-77-0) → 4,6-dichloro-1,3,5-triazin-2-amine (933-20-0)

Guidance literature:

With ammonium hydroxide; In dichloromethane; at 22 - 26 ℃;

DOI:10.1016/j.bmc.2016.04.018

Reference yield:

ammonium hydroxide (1336-21-6) + 1,3,5-trichloro-2,4,6-triazine (108-77-0) → 4,6-dichloro-1,3,5-triazin-2-amine (933-20-0)

Guidance literature:

In water;

Reference yield:

1,3,5-trichloro-2,4,6-triazine (108-77-0) → 4,6-dichloro-1,3,5-triazin-2-amine (933-20-0) + 2-Chloro-4,6-diamino-1,3,5-triazine (3397-62-4)

Guidance literature:

With ammonia; In diethyl ether; 0°C;

DOI:10.1021/jo01105a620

upstream raw materials:

1,3,5-trichloro-2,4,6-triazine

1,4-dioxane

monoethylene glycol diethyl ether

ammonia

Downstream raw materials:

4,6-bis-aziridin-1-yl-[1,3,5]triazin-2-ylamine

4-chloro-6-(morpholin-4-yl)-1,3,5-triazin-2-amine

2-amino-4,6-dimethoxy-1,3,5-triazine

6-chloro-N⁴-propyl-1,3,5-triazine-2,4-diamine

Refernces

• 1、 Shastin,Korepin,Aliev,Korchagin,Glushakova,Malygina,Kosilko,Lodygina,Lagodzinskaya,Aldoshin. "Synthesis and structural study of 4,6-diazido-2-(2,2,2-trinitroethylamino)-1,3,5-triazine". . p. 2469 - 2474. Retrieved 2016.
• 2、 Singh, Sunaina,Aggarwal, Amit,Farley, Christopher,Hageman, Brian A.,Batteas, James D.,Drain, Charles Michael. "Hierarchical organization of a robust porphyrin cage self-assembled by hydrogen bonds". . p. 7134 - 7136. Retrieved 2011.
• 3、 Adhikari, Nayana,Kashyap, Ankita,Shakya, Anshul,Ghosh, Surajit Kumar,Bhattacharyya, Dibya Ranjan,Bhat, Hans Raj,Singh, Udaya Pratap. "Microwave assisted synthesis, docking and antimalarial evaluation of hybrid PABA-substituted 1,3,5-triazine derivatives". . p. 2389 - 2399. Retrieved 2020/03/24.
• 4、 Lolak, Nabih,Akocak, Suleyman,Bua, Silvia,Supuran, Claudiu T.. "Design, synthesis and biological evaluation of novel ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as potent carbonic anhydrase IX inhibitors". . p. 117 - 122. Retrieved 2018/10/20.