2-METHOXYPHENYL-(2-THIENYL)METHANOL

Base Information

• Chemical Name: 2-METHOXYPHENYL-(2-THIENYL)METHANOL
• CAS No.: 356554-06-8
• Molecular Formula: C₁₂H₁₂O₂S
• Molecular Weight: 220.292
• Mol file: 356554-06-8.mol

Synonyms:

Chemical Property of 2-METHOXYPHENYL-(2-THIENYL)METHANOL

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-METHOXYPHENYL-(2-THIENYL)METHANOL

There total 6 articles about 2-METHOXYPHENYL-(2-THIENYL)METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

thiophene boronic acid (6165-68-0) + ortho-anisaldehyde (135-02-4) → (2-methoxyphenyl)-(2'-thienyl)methanol (356554-06-8)

Guidance literature:

thiophene boronic acid; With diethylzinc; In toluene; at 70 ℃; for 6h; Inert atmosphere;

With (S,E)-2-(anthracen-9-ylmethyleneamino)-4-methyl-1,1-diphenylpentan-1-ol; In toluene; at 20 ℃; for 0.5h; Inert atmosphere;

ortho-anisaldehyde; In toluene; at 0 - 20 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.02.059

Reference yield: 72.0%

thiophene-2-carbaldehyde (98-03-3) + 2-bromoanisole (578-57-4) → C12H12O2S (356554-06-8)

Guidance literature:

With 1,10-Phenanthroline; 3-chloroprop-1-ene; trifluoroacetic acid; cobalt(II) bromide; zinc; In acetonitrile; at 80 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201806239

Reference yield:

thiophene-2-carbaldehyde (98-03-3) + 2-Methoxyphenylboronic acid (5720-06-9) → (2-thienyl)(2-methoxyphenyl)methanol (356554-06-8) + (2-thienyl)(2-methoxyphenyl)methanol (356554-06-8)

Guidance literature:

With potassium fluoride; rhodium(III) chloride; bromo[N,N'-bis[(R_p)-(+)-12-methoxy-4-[2.2]paracyclophanyl]imidazol-2-ylidene]silver; In methanol; tert-butyl alcohol; at 40 ℃; for 3h; Overall yield = 81 %; enantioselective reaction; Sonication; Inert atmosphere;

DOI:10.1016/j.tetasy.2013.01.017

upstream raw materials:

thiophene boronic acid

ortho-anisaldehyde

(2-methoxyphenyl)thiophen-2-ylmethanone

thiophene-2-carbaldehyde