(2S,5S)-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolane

Base Information

Chemical Name:(2S,5S)-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolane
CAS No.:113787-28-3
Molecular Formula:C₂₄H₃₂O₈S
Molecular Weight:480.579
Hs Code.:
DSSTox Substance ID:DTXSID70433028
Nikkaji Number:J245.717B
Wikidata:Q27078399
Pharos Ligand ID:U6W56ZL3DS71
Mol file:113787-28-3.mol

Synonyms:113787-28-3;L659989;L-659989;(2S,5S)-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolane;D0MA3D;CHEMBL37781;GTPL3426;SCHEMBL6154076;DTXSID70433028;NZWPFJNQOZFEDT-ROUUACIJSA-N;BDBM50002829;AKOS040748698;L-662,418;Q27078399;L-659,989, (+);(2alpha,5beta)-Tetrahydro-2-[3-methoxy-5-(methylsulfonyl)-4-propoxyphenyl]-5-(3,4,5-trimethoxyphenyl)furan;(2S,5S)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan

Suppliers and Price of (2S,5S)-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
L-659989
100mg
$ 2475.00

TRC
L-659989
250mg
$ 4675.00

Medical Isotopes, Inc.
L-659989
100 mg
$ 3250.00

Total 0 raw suppliers

Chemical Property of (2S,5S)-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolane

Chemical Property:

PSA：97.90000
LogP:5.58690
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:10
Exact Mass:480.18178915
Heavy Atom Count:33
Complexity:681

Purity/Quality:: L-659989 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCOC1=C(C=C(C=C1S(=O)(=O)C)C2CCC(O2)C3=CC(=C(C(=C3)OC)OC)OC)OC
Isomeric SMILES:CCCOC1=C(C=C(C=C1S(=O)(=O)C)[C@@H]2CC[C@H](O2)C3=CC(=C(C(=C3)OC)OC)OC)OC
Uses L-659989 is a platelet-activating factor (PAF) receptor antagonist. L-659989 is also a potent inhibitor of phospholipase D activity at higher concentrations. L-659989 showed cardioprotective effects as it inhibited heart injury from ischemia and reperfusion in rats.

Technology Process of (2S,5S)-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolane

There total 8 articles about (2S,5S)-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 116681-60-8
1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol

: 106331-88-8,113787-28-3,116681-61-9,116781-15-8,116781-16-9,117065-96-0,121702-59-8,121702-60-1,129314-27-8
(2S,5S)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan

: 106331-88-8,113787-28-3,116681-61-9,116781-15-8,116781-16-9,117065-96-0,121702-59-8,121702-60-1,129314-27-8
(2S,5R)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan

Guidance literature:: With trifluoroacetic acid; In chloroform; for 0.583333h; Ambient temperature;
DOI:10.1016/S0040-4039(00)82307-2

Reference yield: 23.0%

: 116681-60-8
1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol

: 106331-88-8,113787-28-3,116681-61-9,116781-15-8,116781-16-9,117065-96-0,121702-59-8,121702-60-1,129314-27-8
(2S,5S)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan

: 106331-88-8,113787-28-3,116681-61-9,116781-15-8,116781-16-9,117065-96-0,121702-59-8,121702-60-1,129314-27-8
(2S,5R)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan

Guidance literature:: With trifluoroacetic acid; In chloroform; for 0.583333h; Ambient temperature;
DOI:10.1016/S0040-4039(00)82307-2

Reference yield:

: 1136-86-3
methyl (3,4,5-trimethoxyphenyl) ketone

: 106331-88-8,113787-28-3,116681-61-9,116781-15-8,116781-16-9,117065-96-0,121702-59-8,121702-60-1,129314-27-8
(2S,5S)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan

Guidance literature:: Multi-step reaction with 3 steps

2: 100 percent / NaBH₄ / ethanol / 1 h / 70 °C / LiAlH₄, THF, RT, 2 h

3: 50 percent / 5percent CF₃COOH / CHCl₃ / 0.58 h / Ambient temperature

With sodium tetrahydroborate; trifluoroacetic acid; In ethanol; chloroform;
DOI:10.1016/S0040-4039(00)82307-2