N-(Benzyloxycarbonyl)-L-alanyl-L-prolyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serin-tert-butylester

Base Information

Chemical Name:N-(Benzyloxycarbonyl)-L-alanyl-L-prolyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serin-tert-butylester
CAS No.:120792-03-2
Molecular Formula:C₅₂H₈₀N₆O₁₉
Molecular Weight:1093.24
Hs Code.:

N-(Benzyloxycarbonyl)-L-alanyl-L-prolyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serin-tert-butylester

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Chemical Property of N-(Benzyloxycarbonyl)-L-alanyl-L-prolyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serin-tert-butylester

Chemical Property:

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Technology Process of N-(Benzyloxycarbonyl)-L-alanyl-L-prolyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serin-tert-butylester

There total 12 articles about N-(Benzyloxycarbonyl)-L-alanyl-L-prolyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serin-tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67817-37-2
3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-D-galactopyranosyl chloride

: 120792-03-2
N-(Benzyloxycarbonyl)-L-alanyl-L-prolyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serin-tert-butylester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Ag₂CO₃, AgClO₄, molecular sieve / 1.) CH₂Cl₂, toluene, 1 h, RT; 2.) 5 d

2: 1.) H₂S; 2.) pyridine / 1.) pyridine, H₂O, 3.5 h, 0 deg C; 24 h ; 2.) 0 deg C, 24 h

3: 95 percent / HCOOH / 20 h / Ambient temperature

4: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 3 h

5: 97 percent / morpholine / 0.67 h

6: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 20 h

With morpholine; pyridine; formic acid; molecular sieve; hydrogen sulfide; silver perchlorate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; silver carbonate; In dichloromethane;

Reference yield:

: 1142-20-7
N-Cbz-Ala

: 120792-03-2
N-(Benzyloxycarbonyl)-L-alanyl-L-prolyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serin-tert-butylester

Guidance literature:: Multi-step reaction with 3 steps

1: NEt₃, 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 24 h

2: 100percent HCOOH / 24 h / Ambient temperature

3: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 20 h

With formic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In dichloromethane;

Reference yield:

: 48067-24-9
O-tert-butyl L-serine tert-butyl ester

: 120792-03-2
N-(Benzyloxycarbonyl)-L-alanyl-L-prolyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serin-tert-butylester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 21 h

2: 73 percent / morpholine / 0.5 h / Ambient temperature

3: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 3 h

4: 97 percent / morpholine / 0.67 h

5: 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / CH₂Cl₂ / 20 h

With morpholine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane;