Technology Process of 3-benzyl-2,3,4,5-tetrahydro-8-methoxy-1-methyl-1,4-ethano-1H-3-benzazepin-5-ol
There total 12 articles about 3-benzyl-2,3,4,5-tetrahydro-8-methoxy-1-methyl-1,4-ethano-1H-3-benzazepin-5-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 4h;
Heating;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 81 percent / sodium, iron(III) nitrate / liquid ammonia; diethyl ether / 2.5 h / -78 °C
2: 70 percent / 1.) n-butyl-lithium/di-isopropylamine; 2.) HMPA / tetrahydrofuran / 0.25 h / -72 °C
3: 60 percent / sodium hydroxide / aq. ethanol / 18 h / Heating
4: 76 percent / polyphosphoric acid / 24 h / 45 °C
5: 76 percent / sodium hydride / toluene / 3 h / 75 °C
6: 83 percent / phenyltrimethylammonium perbromide / tetrahydrofuran / 1 h / 0 °C
7: 76 percent / sodium hydride, 15-crown-5-ether / toluene / Ambient temperature
8: 46 percent / lithium aluminium hydride / tetrahydrofuran / 4 h / Heating
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; PPA; 15-crown-5; sodium; phenyltrimethylammonium tribromide; sodium hydride; ferric nitrate; diisopropylamine;
In
tetrahydrofuran; diethyl ether; ethanol; ammonia; toluene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 80 percent / conc. sulphuric acid / 2.5 h / Heating
2: 81 percent / sodium, iron(III) nitrate / liquid ammonia; diethyl ether / 2.5 h / -78 °C
3: 70 percent / 1.) n-butyl-lithium/di-isopropylamine; 2.) HMPA / tetrahydrofuran / 0.25 h / -72 °C
4: 60 percent / sodium hydroxide / aq. ethanol / 18 h / Heating
5: 76 percent / polyphosphoric acid / 24 h / 45 °C
6: 76 percent / sodium hydride / toluene / 3 h / 75 °C
7: 83 percent / phenyltrimethylammonium perbromide / tetrahydrofuran / 1 h / 0 °C
8: 76 percent / sodium hydride, 15-crown-5-ether / toluene / Ambient temperature
9: 46 percent / lithium aluminium hydride / tetrahydrofuran / 4 h / Heating
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; PPA; 15-crown-5; sulfuric acid; sodium; phenyltrimethylammonium tribromide; sodium hydride; ferric nitrate; diisopropylamine;
In
tetrahydrofuran; diethyl ether; ethanol; ammonia; toluene;
